Search for dissertations about: "antipsychotic activity"

Showing result 1 - 5 of 23 swedish dissertations containing the words antipsychotic activity.

  2. 1. Arylpiperidine and arylpyrrolidine derivatives with potential antipsychotic efficacy : synthesis and quantitative structure-activity relationships

    Author : Clas Sonesson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  4. 2. Dopaminergic stabilizers for the treatment of schizophrenia. Rat studies focusing on negative symptoms and mechanisms of action

    Author : Johan P. Rung; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ACR16; dopaminergic stabilizers; -MK-801; motor activity; negative symptoms; - -OSU6162; prolactin; rat; schizophrenia; social withdrawal;

    Abstract : Schizophrenia is a severe mental disorder manifested by positive, negative and cognitive symptoms. Current antipsychotic drugs have poor effects on negative and cognitive symptoms, thus necessitating the development of new antipsychotic treatments. Dopaminergic stabilizers constitute a novel concept for the treatment of schizophrenia. READ MORE

  5. 3. Modulation of prefrontal glutamatergic transmission and 'atypicality' of antipsychotic drugs

    Author : Åsa Konradsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The glutamate hypothesis of schizophrenia suggests a relationship between hypoactive NMDA receptor-mediated glutamatergic transmission and the pathophysiology of schizophrenia. Previous results have demonstrated that atypical (e.g. clozapine, risperidone, and olanzapine), but not typical (e. READ MORE

  6. 4. On the mechanisms of action of atypical antipsychotic drugs : an experimental study

    Author : Peter Hertel; Karolinska Institutet; Karolinska Institutet; []
    Keywords : antipsychotic drugs; dopamine; serotonin; medial prefrontal cortex; dorsal raphe nucleus; risperidone; clozapine; idazoxan; [alpha]2 adrenoceptors; conditioned avoidance; catalepsy;

    Abstract : A majority of schizophrenic patients respond to classical neuroleptic drugs which are believed to act largely via blockade of dopamine (DA) D2 receptors in limbic structures. However, a significant proportion do not respond to conventional D2 receptor blocking drugs or show a rather incomplete therapeutic effect, particularly on negative and cognitive symptoms. READ MORE

  7. 5. Mode of action of asenapine vs. other antipsychotic drugs : an experimental analysis

    Author : Olivia Frånberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Antipsychotic drugs (APDs) are used in the treatment of schizophrenia and manic or mixed episodes associated with bipolar I disorder. Generally, the so-called atypical APDs, such as clozapine, may in contrast to typical APDs improve not only positive, but also negative symptoms and some aspects of cognitive impairment associated with schizophrenia. READ MORE