Search for dissertations about: "antipsychotic agents"

Showing result 1 - 5 of 10 swedish dissertations containing the words antipsychotic agents.

2. 1. Influence of antipsychotic drugs on hormone levels

   Author : Kristina Melkersson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : antipsychotic agents; prolactin; growth hormone; insulin-like growth factor 1; insulin; leptin; lipids; side effects; weight gain; metabolic syndrome;

   Abstract : The aim of the studies summarized in this thesis was to investigate the influence of antipsychotic drugs on hormone levels, in order to identify causes of hormonally related side effects of these drugs. The effect of antipsychotics on the prolactin (PRL) secretion, the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis and the glucose-insulin homeostasis was studied. READ MORE

4. 2. Modulation of prefrontal glutamatergic transmission and 'atypicality' of antipsychotic drugs

   Author : Åsa Konradsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The glutamate hypothesis of schizophrenia suggests a relationship between hypoactive NMDA receptor-mediated glutamatergic transmission and the pathophysiology of schizophrenia. Previous results have demonstrated that atypical (e.g. clozapine, risperidone, and olanzapine), but not typical (e. READ MORE

5. 3. Recognition of dementia with Lewy bodies. Prevalence of core signs, medical treatments and survival in Swedish nursing homes and short-term homes

   Author : Iris Zahirovic; Klinisk minnesforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DEMENTIA; Dementia care; Lewy Body Disease; Geriatric Medicine; Neurocognitive disorders; Antipsychotic Agents therapeutic use; Survival; Prevalence of symptoms;

   Abstract : Dementia with Lewy bodies (DLB) is an underdiagnosed neurocognitive disorder thatincludes several complex neurological and psychological signs, which are challenging toclinical diagnostics. The recognition of this neurocognitive disorder should beimproved because people with DLB exhibit a good treatment response to anti-dementiamedications but experience severe adverse events if treated with anti-psychoticmedicine. READ MORE

6. 4. Movement pattern analysis of hypoglutamatergic mice. A model for cognitive deficits of schizophrenia and autism?

   Author : Marie Nilsson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; schizophrenia; autism; cognition; movement pattern; video tracking; MK-801; mice;

   Abstract : Schizophrenia and autism are two severe neuropsychiatric disorders that are associated withprofound cognitive disturbances which considerably contribute to the long-term morbidity andthe decreased ability to function in the society. Currently used therapies do not reach the corecognitive disturbances to a satisfactory extent. READ MORE

7. 5. A pharmacokinetic approach to intra-brain distribution with a focus on cyclic peptides

   Author : Erik Melander; Margareta Hammarlund-Udenaes; Irena Loryan; Ulf Göransson; Xavier Declèves; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

   Abstract : When designing treatments for disorders of the central nervous system (CNS) reaching the site of action is a major hurdle in the development process. Regardless if the target is extra- or intracellular, precise measurements to understand the distribution within the CNS are required. READ MORE