Search for dissertations about: "antipsychotic schizophrenia"

Showing result 1 - 5 of 43 swedish dissertations containing the words antipsychotic schizophrenia.

  2. 1. Finding improved drug strategies for schizophrenia : Preclinical studies on lumateperone and sodium nitroprusside

    Author : Joep Titulaer; Åsa Konradsson-Geuken; Anne-Lie Svensson; Erika Roman; Kent Jardemark; Joshua Beckmann; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; schizophrenia; lumateperone; sodium nitroprusside; antipsychotic drugs; Farmaceutisk vetenskap; Pharmaceutical Science; Pharmacology; Farmakologi; Psychiatry; Psykiatri;

    Abstract : Schizophrenia is a severe psychiatric disorder affecting approximately 20 million people worldwide. The disease consists of positive symptoms e.g. hallucinations, negative symptoms such as anhedonia, and cognitive deficits, e. READ MORE

  4. 2. Pharmacogenetics and Antipsychotic Treatment in Schizophrenia with Special Focus on Adverse Drug Reactions

    Author : Arzu Gunes; Marja-Liisa Dahl; Maria Gabriella Scordo; Kristina I. Melkersson; Jürgen Brockmöller; Uppsala universitet; []
    Keywords : Medicine; Pharmacogenetics; schizophrenia; antipsychotic treatment; adverse effects; clinical outcome; Medicin;

    Abstract : Genetically determined differences in drug metabolism and disposition and drug targets play a pivotal role in the interindividual variability in the clinical outcome of antipsychotic treatment. The aim of this thesis was to study the impact of polymorphisms in genes involved in the pharmacokinetics and pharmacodynamics of antipsychotics, with special focus on their extrapyramidal and metabolic adverse effects. READ MORE

  5. 3. PET applications in schizophrenia : Functional and pharmacological dopamine studies

    Author : Ola Gefvert; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Schizophrenia; PET; dopamine synthesis rate; dopamine D2 receptor occupancy; atypical antipsychotics; quetiapine; risperidone microsphere depot; Neurovetenskap; Neurology; Neurologi; Psychiatry; psykiatri;

    Abstract : Schizophrenia is a group of disorders with a worldwide lifetime prevalence of 0.85%. Thefunctional outcome of the disorder seem stable from the first systematic outcome studies to thepresent day, and vary only with changes in diagnostic criteria. READ MORE

  6. 4. Suicide in schizophrenia and adverse events during antipsychotic medication

    Author : Eric Clapham; Robert Bodén; Johan Reutfors; Helle Kieler; Ursula Werneke; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; schizophrenia; antipsychotics; clozapine; suicide; osteoporosis; myocarditis; Psychiatry; Psykiatri;

    Abstract : This thesis considers side effects and other adverse events during treatment with antipsychotic medication. All included studies use an epidemiological methodology with data from Swedish population-based health registers. The first two studies utilise a nested case-control design, whereas the third and fourth studies rely on cohort designs. READ MORE

  7. 5. Cognition, Adherence and Stigma in Schizophrenia. The COAST study

    Author : Cecilia Brain; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; schizophrenia; adherence; Medication Event Monitoring System; antipsychotics; pill count; drug attitude; stigma; discrimination; relatives´burden;

    Abstract : Schizophrenia is a serious stigmatizing illness. Antipsychotic medication is a cornerstone in treatment. Non-adherence is a predictor of poor outcome leading to relapse, poor functioning, high mortality and costs. Reported adherence rates vary (8-86%). READ MORE