Search for dissertations about: "antipsychotics"

Showing result 1 - 5 of 37 swedish dissertations containing the word antipsychotics.

  1. 1. Effects of antipsychotics on GABA neurons in the basal ganglia of the rat

    Author : Jiang Yu; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; antipsychotics; γ-aminobutyric acid; glutamic acid decarboxylase; basal ganglia; entopeduncular nucleus; vacuous chewing movements; Neurovetenskap; Neurology; Neurologi; Psychiatry; psykiatri;

    Abstract : Antipsychotics are used in the treatment of psychosis and, based on their propensities to induce extrapyramidal side effects (EPS), are divided into typical (haloperidol) and atypical (clozapine) subtypes. The incidence of EPS, arises from an imbalance in the neurotransmission between two majorGABAergic pathways of the basal ganglia that connect the striatum directly to the entopeduncular nucleus (EP) and the substantia nigra reticulata or indirectly via the globus pallidus and the subthalamic nucleus. READ MORE

  2. 2. Cognition, Adherence and Stigma in Schizophrenia. The COAST study

    Author : Cecilia Brain; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; schizophrenia; adherence; Medication Event Monitoring System; antipsychotics; pill count; drug attitude; stigma; discrimination; relatives´burden;

    Abstract : Schizophrenia is a serious stigmatizing illness. Antipsychotic medication is a cornerstone in treatment. Non-adherence is a predictor of poor outcome leading to relapse, poor functioning, high mortality and costs. Reported adherence rates vary (8-86%). READ MORE

  3. 3. Drug-related morbidity and mortality : Pharmacoepidemiological aspects

    Author : Anna K. Jönsson; Staffan Hägg; Johan Ahlner; Henrik Druid; Jörg Mörland; Linköpings universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adverse drug reactions; pharmacoepidemiology; antipsychotics; venous; thromboembolism; warfarin; haemorrhage; intoxication; medico-legal autopsies; mortality; Läkemedelsbiverkningar; farmakoepidemiologi; antipsykotika; venös tromboembolism; warfarin; blödning; intoxikation; rättsmedicinska obduktioner; fatal; Clinical pharmacology; Klinisk farmakologi;

    Abstract : Adverse drug reactions (ADRs) constitute a significant health problem with consequences for the patient as well as for society. Suspected ADRs have been reported to occur in about 2-14% of hospitalised patients. In about 5% of deceased hospitalised patients suspected ADRs may have caused or contributed to the fatal outcome. READ MORE

  4. 4. PET applications in schizophrenia : Functional and pharmacological dopamine studies

    Author : Ola Gefvert; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Schizophrenia; PET; dopamine synthesis rate; dopamine D2 receptor occupancy; atypical antipsychotics; quetiapine; risperidone microsphere depot; Neurovetenskap; Neurology; Neurologi; Psychiatry; psykiatri;

    Abstract : Schizophrenia is a group of disorders with a worldwide lifetime prevalence of 0.85%. Thefunctional outcome of the disorder seem stable from the first systematic outcome studies to thepresent day, and vary only with changes in diagnostic criteria. READ MORE

  5. 5. Influence of antipsychotic drugs on hormone levels

    Author : Kristina Melkersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; antipsychotic agents; prolactin; growth hormone; insulin-like growth factor 1; insulin; leptin; lipids; side effects; weight gain; metabolic syndrome;

    Abstract : The aim of the studies summarized in this thesis was to investigate the influence of antipsychotic drugs on hormone levels, in order to identify causes of hormonally related side effects of these drugs. The effect of antipsychotics on the prolactin (PRL) secretion, the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis and the glucose-insulin homeostasis was studied. READ MORE