Search for dissertations about: "antiretroviral therapy"

Showing result 1 - 5 of 107 swedish dissertations containing the words antiretroviral therapy.

  1. 1. Low-level HIV viremia during antiretroviral therapy

    Author : Olof Elvstam; Klinisk infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human immunodeficiency virus; Viral load; Antiretroviral therapy; Mortality; Malignancies; Cardiovascular disease;

    Abstract : In most cases, antiretroviral therapy (ART) results in undetectable plasma HIV viral load (VL). Still, up to 25% of ART recipients may have detectable low-level viremia (LLV) of different amplitude and persistence. This thesis explores the impact of LLV during ART on virologic and clinical outcomes. READ MORE

  2. 2. Antiretroviral treatment of HIV-1 in Sweden with focus on virological aspects

    Author : Erik Sörstedt; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; antiretroviral therapy; transient viremia; viral blip; nucleoside transcriptase inhibitor resistance; dolutegravir; baseline viral load; HIV RNA; virological failure;

    Abstract : From a clinical standpoint, there are many factors to consider when optimizing the care for people living with HIV (PLWH). With help from clinical guidelines, most obstacles can be addressed. Expanded knowledge is however in constant demand, from local conditions to universal processes. READ MORE

  3. 3. HIV-1 infection of the central nervous system. Markers of pathogenesis and antiretroviral treatment effects

    Author : Sahra Abdulle; Göteborgs universitet; []
    Keywords : HIV-1; cerebrospinal fluid; antiretroviral therapy; neopterin; beta2-microglobulin; CSF HIV-1 RNA; blood-brain barrier; IgG index; HIV-related neurological diseases; AIDS Dementia Complex; neurofilament protein; HIV-1 genetic subtypes;

    Abstract : Human immunodeficiency virus type 1 (HIV-1) invades the central nervous system (CNS) early in the course of infection and either directly or through opportunistic infections causes a spectrum of neurological complications. The most severe manifestation of HIV-1 CNS infection is AIDS Dementia Complex (ADC), which occurs in approximately 20% of untreated patients with AIDS. READ MORE

  4. 4. Lost in transition : pre-antiretroviral care and delayed initiation of antiretroviral therapy in Uganda

    Author : Muhamadi Lubega; Karolinska Institutet; Karolinska Institutet; []
    Keywords : counselling;

    Abstract : Background: Comprehensive HIV care aims at providing care and support, from HIV counselling and testing, through pre-antiretroviral (pre-ARV) care to antiretroviral therapy (ART). However, many people living with HIV (PLHIV) do not start treatment or are lost to follow-up during pre-ARV care, and subsequently initiate ART very late, with a high risk of HIV/AIDS-related mortality. READ MORE

  5. 5. HIV Persistence and Viral Reservoirs

    Author : Arvid Edén; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; antiretroviral therapy; latency; cerebrospinal fluid; central nervous system; efavirenz; lopinavir; atazanavir; neopterin; viral decay;

    Abstract : Although antiretroviral therapy (ART) can effectively inhibit replication of human immunodeficiency virus type 1 (HIV-1), the virus is able to persist in cellular and anatomical viral reservoirs. Latently infected resting memory CD4+ T-cells are an important cellular reservoir, and the central nervous system (CNS) an important anatomical reservoir for HIV-1 infection. READ MORE