Search for dissertations about: "antisense oligonucleotide"
Showing result 11 - 15 of 23 swedish dissertations containing the words antisense oligonucleotide.
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11. Development of a new PNA analogue as a potential antisense drug and tool for life-science studies
Abstract : The work described in this thesis focuses on applying synthetic organic chemistry methods (supported by modem synthesizers and analytical techniques) for the preparation of peptides and modified nucleic acids in order to affect certain properties in these biomolecules, which can lead to their application as drugs and/or tools for life sciences studies. The first part of the thesis reports the design and synthesis of a novel pyrrolidine-based peptide nucleic acid (PNA). READ MORE
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12. Development of a novel methodology for the synthesis of oligonucleo-peptide conjugates
Abstract : Peptide-oligonucleotide conjugates constitute a new class of antisense molecules that exhibit improved biological activity over standard oligonucleotide analogues. Currently, these oligomeric bioconjugates are prepared by either solution- or solid-phase techniques. READ MORE
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13. EBV gene variation and epigenetic alterations in asian nasopharyngeal carcinoma and potential clinical applications
Abstract : The incidence of nasopharyngeal carcinoma (NPC), an epithelial tumor, varies remarkably in different geographic regions and human populations. The Epstein-Barr virus (EBV), other environmental factors and genetic susceptibility are all considered to be involved in the etiology of this form of cancer and the EBV has been extensively studied in this context. READ MORE
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14. Carbon-Carbon Bond Formation via Radical Cyclization and Transition Metal Catalysis
Abstract : Free radical cyclization methodology has been used extensively in synthesis for manipulation of complex molecules such as alkaloids, terpenes, carbohydrates, peptides and nucleic acids. The methodology has emerged as a result of work by physical organic chemists who determined rate constants for the most common radical reactions used in organic synthesis. READ MORE
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15. Cell-penetrating peptides and bioactive cargoes : Strategies and mechanisms
Abstract : The cell membrane is an impermeable barrier for most macromolecules. Recently discovered cell-penetrating peptides (CPPs) have gained lot of attention because they can cross the membrane, and even more, carry cargoes with them. How CPPs enter cells is still not clear, while the delivery of different cargoes has been convincingly shown. READ MORE
