Search for dissertations about: "antisense oligonucleotide"
Showing result 16 - 20 of 23 swedish dissertations containing the words antisense oligonucleotide.
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16. Nucleic acid in gene delivery and gene regulation
Abstract : The concept of gene therapy, initially attributed to a technology that would allow the correction of inherited genetic disease, has evolved over the years. The realization of the immense technical hurdles to achieve genetic correction led to a broadening of the concept now including the transfer of genetic material whose expression will counteract, mitigate or revert a disease phenotype. READ MORE
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17. Design and application of RNA therapeutics for splice site mutations
Abstract : Precursor messenger RNA splicing is one of the most fundamental and complex mechanisms in eukaryotes. Over 90% of the human genes undergo alternative splicing, which is essential for the regulation of gene expression. A dynamic RNA-protein complex called the spliceosome catalyzes splicing. READ MORE
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18. Delivery of gene-regulating agents : internalization mechanisms and novel vectors
Abstract : The sequencing of the human genome was expected to generate a veritable explosion of therapeutics for regulation of gene function, either through modulation of gene expression or through the replacement of defect genes. However, nucleic acid-based pharmacological agents suffer from issues of low bioavailability and unfavorable pharmacokinetics, wherefore these prospects have not yet been realized. READ MORE
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19. Cell-penetrating peptides and oligonucleotides : Design, uptake and therapeutic applications
Abstract : Regulation of biological processes through the use of genetic elements is a central part of biological research and also holds great promise for future therapeutic applications. Oligonucleotides comprise a class of versatile biomolecules capable of modulating gene regulation. READ MORE
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20. Padlock probes : Circularizing oligonucleotides for localized detection of DNA sequence variants
Abstract : Present techniques for localized detection of DNA sequence variants have limitations due to problems with sensitivity, specificity, signal localization or ability to perform many analyses simultaneously.In this study a novel gene analytic reagent is presented - the padlock probe. READ MORE