Search for dissertations about: "antisense oligonucleotide"
Showing result 21 - 23 of 23 swedish dissertations containing the words antisense oligonucleotide.
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21. Molecular dynamics simulations of RNA bulges, loops and base flipping
Abstract : RNA molecules have several important functions in a cell. They carry the genetic information from DNA to protein, act as catalysts and regulate gene expression. Both DNA and RNA consist of nucleotides, DNA molecules are mainly double stranded while RNA molecules often have single stranded regions that interrupt the double stranded structure. READ MORE
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22. Mimicking the action of ribonucleases : studies on RNase A and design of PNA based artificial enzymes
Abstract : A 3’-deoxy-3’-C-methylenephosphonate modified diribonucleotide is highly resistant to degradation by spleen phosphodiesterase and not cleaved at all by snake venom phosphodiesterase. Despite that both the vicinal 2-hydroxy nucleophile and the 5’-oxyanion leaving group are intact, the 3’-methylenephosponate RNA modification is also highly resistant towards the action of RNase A. READ MORE
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23. DNA analogs for the purpose of gene therapy
Abstract : This thesis describes DNA analogs and their potential use for gene therapeutic purposes, primarily by sequence specific strand-invasion of double-stranded DNA. Gene therapy is classically thought of as restoration of a defect gene. READ MORE
