Search for dissertations about: "antisense oligonucleotide"

Showing result 6 - 10 of 23 swedish dissertations containing the words antisense oligonucleotide.

  2. 6. Towards smart antisense and antigene therapeutics : design and synthesis of novel oligonucleotide based bioconjugates

    Author : Martina Jezowska-Herrera; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The use of nucleic acid technology has been of great importance in life science research. In several clinical trials patients with genetic disease are treated with help of innovations based on oligonucleotide therapy. The use of it is unfortunately limited in efficacy due to e.g. READ MORE

  4. 7. MST3 and MST4: Critical Regulators of Liver Lipid Partitioning and Hepatocarcinogenesis

    Author : Mara Caputo; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; hepatocellular carcinoma; STE20-type kinases; MST3; MST4; lipid droplets; antisense oligonucleotide treatment; fibrosis;

    Abstract : Non-alcoholic fatty liver disease (NAFLD) encompasses a disease spectrum ranging from hepatic steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, and finally cirrhosis. With no approved pharmacological treatment, NAFLD is currently the most common etiology of chronic liver disease in Western countries and its prevalence continues to grow. READ MORE

  5. 8. Development of oligonucleotide based artificial ribonucleases 2'-O-MeOBAN´s and PNAzymes

    Author : Merita Murtola; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The present thesis is based on three parts. The first and second part describe the development of two different classes of metal-ion dependent artificial ribonucleases, 2'-O-methyl-ribonucleic acid based artificial ribonucleases (2'-O-MeOBANs) and peptide nucleic acid based artificial ribonucleases (PNAzymes). READ MORE

  6. 9. Studies on phosphate ester cleavage and development of oligonucleotide based artificial nucleases (OBAN’s)

    Author : Hans Åström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Five different Oligonucleotide Based Artificial Nuclease (OBAN) systems have been synthesized. OBAN's may be regarded as a development of traditional antisense methodology where inhibition of gene expression can be achieved by hybridizing a synthetic oligonucleotide to natural mRNA and thus inhibiting further translation into protein products. READ MORE

  7. 10. Optimization of the formulation and design of oligonucleotide-based pharmaceuticals for the purpose of gene therapy

    Author : Eman M Zaghloul; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Oligonucleotides (ONs) are short sequences of nucleic acids which may be used in a therapeutic context to modulate gene expression. According to their target, ONs can be classified into two main classes: antisense ONs which target mRNA and antigene ONs that target chromosomal DNA. READ MORE