Search for dissertations about: "antisense oligonucleotides"
Showing result 16 - 20 of 53 swedish dissertations containing the words antisense oligonucleotides.
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16. Quantitative NanoSIMS provides subcellular concentration and distribution of oligonucleotide therapeutics
Abstract : Antisense oligonucleotides (ASOs) represent a powerful therapeutic modality that can selectively modulate gene expression. However, ASOs face two major hurdles that restrict their use in the clinic. The first issue is delivery of the ASO to a tissue of therapeutic interest while reducing exposure to unrelated tissues. READ MORE
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17. Towards smart antisense and antigene therapeutics : design and synthesis of novel oligonucleotide based bioconjugates
Abstract : The use of nucleic acid technology has been of great importance in life science research. In several clinical trials patients with genetic disease are treated with help of innovations based on oligonucleotide therapy. The use of it is unfortunately limited in efficacy due to e.g. READ MORE
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18. Development of a new PNA analogue as a potential antisense drug and tool for life-science studies
Abstract : The work described in this thesis focuses on applying synthetic organic chemistry methods (supported by modem synthesizers and analytical techniques) for the preparation of peptides and modified nucleic acids in order to affect certain properties in these biomolecules, which can lead to their application as drugs and/or tools for life sciences studies. The first part of the thesis reports the design and synthesis of a novel pyrrolidine-based peptide nucleic acid (PNA). READ MORE
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19. MST3 and MST4: Critical Regulators of Liver Lipid Partitioning and Hepatocarcinogenesis
Abstract : Non-alcoholic fatty liver disease (NAFLD) encompasses a disease spectrum ranging from hepatic steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, and finally cirrhosis. With no approved pharmacological treatment, NAFLD is currently the most common etiology of chronic liver disease in Western countries and its prevalence continues to grow. READ MORE
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20. Development of a novel methodology for the synthesis of oligonucleo-peptide conjugates
Abstract : Peptide-oligonucleotide conjugates constitute a new class of antisense molecules that exhibit improved biological activity over standard oligonucleotide analogues. Currently, these oligomeric bioconjugates are prepared by either solution- or solid-phase techniques. READ MORE