Search for dissertations about: "antitumour"
Showing result 1 - 5 of 16 swedish dissertations containing the word antitumour.
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1. Cytotoxic Compounds of Plant Origin – Biological and Chemical Diversity
Abstract : The development of resistance by tumour cells to chemotherapeutic agents is a major problem in cancer treatments. One way to counter this is to find compounds with cytotoxic mechanisms other than those of drugs in clinical use today. READ MORE
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2. Tumour models in vitro : on the use of multicellular spheroids in studies of antitumour drugs
Abstract : .... READ MORE
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3. Application of new methodology for preclinical development of anticancer drugs : With special focus on camptothecin derivatives and the cyanoguanidine CHS 828
Abstract : This work describes the development and evaluation of new methods for preclinical anticancer drug development. The methods were specifically applied to study camptothecin analogues and the new compound CHS 828 (N-(4-chlorophenoxyhexyl)-N'-cyano-N"-4-pyridylguanidine) currently in early clinical trials. READ MORE
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4. Pharmacological Studies of CHS 828 and Etoposide Induced Tumour Cell Death
Abstract : Antitumour properties of the cyanoguanidine CHS 828 and analogues were discovered in 1997. CHS 828 is presently in clinical phase I/II trials. This thesis encompasses in vitro studies of the kinetics and mode of cell death induced in the human cell line U-937 GTB, by CHS 828 and the standard antitumour drug etoposide. READ MORE
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5. Cisplatin induced ototoxicity : pharmacokinetics, prediction and prevention
Abstract : Cisplatin is an anticancer drug used against a number of malignancies e.g. testicular cancer, ovarian cancer and some paediatric malignancies. The main dose limiting side effects of cisplatin are oto- and neurotoxicity. READ MORE