Search for dissertations about: "antiviral"

Showing result 11 - 15 of 224 swedish dissertations containing the word antiviral.

  2. 11. Structure-aided design of antiviral drugs : Application of the method on HIV-1 protease and SIV reverse transcriptase

    Author : Hans Ola Andersson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; HIV; protease; SIV; reverse transcriptase; structure; inhibitor; drug design; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Many efforts have been made to control the AIDS epidemic. Extensive studies have been done on the biology, biochemistry, and structural biology of HIV in the search for antiviral drugs. The viral-encoded enzymes reverse transcriptase and protease have been main targets for drug design. READ MORE

  4. 12. Hepatitis C virus kinetics during antiviral treatment

    Author : Tony Carlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hepatitis C virus RNA; genotype; kinetics; interferon-alpha; ribavirin.;

    Abstract : It is estimated that 170 million individuals have chronic hepatitis C virus (HCV) infection, whereof 20-30% will develop end stage liver disease within 20-30 years. Antiviral therapy can stop this deterioration and clear the infection in 40-80% of the patients depending on treatment and HCV genotype. READ MORE

  5. 13. Resistance to antiviral drugs in HIV and HBV

    Author : Anna Lindström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; HBV; drug-resistance; Sanger sequencing; pyrosequencing;

    Abstract : Development of resistance to antiviral drugs is a major problem in treatment of several viral infections including human immunodeficiency type 1 (HIV-1) and hepatitis B virus (HBV). Resistance may be the primary reason for treatment failure, but may also develop secondary to problems with adherence or pharmacokinetics. READ MORE

  6. 14. Herpesvirus-induced enzymes as targets for antiviral compounds

    Author : Alf Larsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  7. 15. Immunoglobulin gene usage and affinity maturation in antiviral antibodies

    Author : Pradeepa Pushparaj; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The ability of antibodies to block infections makes them highly relevant for successful vaccine development. Through the papers described in this thesis, I attempt to characterize the functional and genetic aspects of antiviral antibodies induced by infection and vaccination. READ MORE