Search for dissertations about: "apo protein"

Showing result 1 - 5 of 66 swedish dissertations containing the words apo protein.

2. 1. Protein folding studies of human superoxide dismutase and ALS associated mutants

   Author : Mikael Lindberg; Mikael Oliveberg; Jane Clarke; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; superoxide dismutase; ALS; protein folding; equilibrium titration; protein stability; apo protein; disulphide bridge; chevron plot; Biokemi; Biochemistry; Biokemi; Biochemistry; biokemi;

   Abstract : Proteins are among the most abundant biological macromolecules. The cellular machinery is coupled to exact structural shape and properties of the more than 100 000 different proteins. Still, proteins can sometimes completely change their character and as a result trigger neuro degenerative disease. READ MORE

4. 2. Zinc in folding and misfolding of SOD1 : Implications for ALS

   Author : Lina Leinartaité; Mikael Oliveberg; Bengt-Harald Jonsson; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein stability; protein misfolding; local unfolding; metal binding; energy landscape; protein disease; amyotrophic lateral sclerosis; Biochemistry; biokemi;

   Abstract : Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease causing degeneration of upper and lower motor neurons. Most ALS cases are sporadic; only 6% are associated with mutations in Cu, Zn superoxide dismutase (SOD1). READ MORE

5. 3. Protein folding variants, for better or for worse? The lesson learned from HAMLET

   Author : Malin Svensson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical biology; prion; apo; fatty acid; apoptosis; lactalbumin; folding variant; Klinisk biologi;

   Abstract : By varying its secondary or tertiary structure a single protein can attain new biological functions. The amyloid forming proteins are the best known examples where a change in conformation leads to the formation of amyloid fibrils that accumulate in tissues and cause disease. READ MORE

6. 4. Protein Interactions: Electrostatics and Ligand Binding

   Author : Ingemar André; Biofysikalisk kemi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biophysics; Molekylär biofysik; secondary structure formation; protein GB1; pKa values; pH stability; NMR; electrostatic interactions; M proteins; calbindin D9k; calcium binding; cooperativity; calmodulin; calbindin D28k;

   Abstract : This thesis deals with Ca2+ binding to proteins, electrostatic interactions in and between proteins as well as inter- and intramolecular interactions. A computer program was developed to determine Ca2+ binding constants from experimental titration data of proteins. READ MORE

7. 5. Heme Protein Biogenesis - Catalase in Enterococcus faecalis

   Author : Michael Baureder; Molekylär cellbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Enterococcus faecalis; heme proteins; protein assembly; oxidative stress; catalase; cytochrome;

   Abstract : Heme proteins form a large and diverse group of proteins which are involved in a variety of biological functions. The heme prosthetic group enables them to carry out redox reactions, transport electrons, bind gaseous molecules, and function as sensors. Despite their importance only little is generally known about heme protein biogenesis. READ MORE