Search for dissertations about: "apolipoprotein-e"

Showing result 1 - 5 of 74 swedish dissertations containing the word apolipoprotein-e.

  2. 1. Peripheral apolipoprotein E and its emerging role in neurodegenerative disease

    Author : Andreas Giannisis; Henrietta M. Nielsen; Kim Kultima; Johan Ankarklev; Cheryl Wellington; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; apolipoprotein E; humanized-liver mice; race; diet; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : The human apolipoprotein E gene (APOE) is polymorphic and coding for three common alleles; ε2, ε3, and ε4. Carriers of the ε4 allele are at a higher risk of developing sporadic late-onset Alzheimer’s Disease (AD). This association appears to be influenced by inherited traits, race, and sex. READ MORE

  4. 2. Cholesterol and apolipoprotein E in suicidal behavior

    Author : Peter Asellus; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Introduction: Low cholesterol has repeatedly been associated with an increased risk of suicidal and violent behavior. The increase in risk is believed to be associated with alterations in serotonergic signaling, which is associated with low cholesterol. READ MORE

  5. 3. Apolipoprotein E and Alzheimer's diseases : signals and effects

    Author : Ángel Cedazo-Minguez; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer's Disease (AD) is the most frequent cause of dementia in the elderly. A diagnosis of AD is confirmed post-mortem by the accumulation of neuritic plaques (NP) and neurofibrillary tangles (NFTs) in brain tissue. READ MORE

  6. 4. Apolipoprotein E and cholinergic enzymes : the interface in dementia

    Author : Swetha Vijayaraghavan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The main confirmed genetic risk factor for sporadic form of Alzheimer’s disease (AD) is apolipoprotein E (ApoE) ε4 allele (APOE4). ApoE protein aids in receptor ligand mediated transport, distribution and metabolism of fatty acids and cholesterol. READ MORE

  7. 5. Heparan Sulfate in the Amyloidosis and Inflammation of Alzheimer’s Disease

    Author : Paul O'Callaghan; Xiao Zhang; Lars Lannfelt; Jeremy Turnbull; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; amyloidosis; amyloid-β; apolipoprotein E; astrocytes; glia; heparanase; heparan sulfate; heparan sulfate proteoglycans; microglia; neuroinflammation; Geriatrics; Geriatrik; Cellforskning; Cell Research; Neuroscience; Neurovetenskap; Pathology; Patologi;

    Abstract : Alzheimer’s disease (AD) is a neurodegenerative disorder, with extensive evidence implicating the misfolding, aggregation and deposition of the amyloid-β (Aβ) peptide as central to the pathogenesis. Heparan sulfate (HS) is an interactive glycosaminoglycan, attached to core proteins as HS proteoglycans (HSPGs). READ MORE