Search for dissertations about: "apoptosis-inducing factor"

Showing result 1 - 5 of 30 swedish dissertations containing the words apoptosis-inducing factor.

  1. 1. Targeting apoptosis-inducing factor as a novel therapeutic strategy for preventing perinatal brain injury

    Author : Juan Rodriguez; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AIF; neonatal; mouse; hypoxia-ischemia; AIF CypA complex; apoptosis; asphyxia; CHCHD4;

    Abstract : Perinatal complications such as asphyxia can cause brain injuries that are often associated with subsequent neurological deficits. The mechanisms of perinatal brain injury are not fully understood, but mitochondria play a prominent role, not only due to their central function in metabolism, but also because many proteins with apoptosisrelated functions are located in the mitochondrion. READ MORE

  2. 2. Oxidant-induced cell death in lymphocytes: mechanisms of induction and resistance

    Author : Fredrik Bergh Thorén; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : reactive oxygen species; cell death; apoptosis; poly ADP-ribose polymerase-1; apoptosis-inducing factor; natural killer cells; phagocytes; dendritic cells;

    Abstract : Reactive oxygen species (oxidants, oxygen radicals) produced by the phagocytic NADPH oxidase have pivotal roles in immunity. Patients lacking a functional NADPH oxidase suffer from chronic granulomatous disease, which is characterized by recurring bacterial infections and thus manifesting the importance of reactive oxygen species in host defense against bacteria. READ MORE

  3. 3. Caspase-dependent and caspase-independent neuronal injury in the developing brain

    Author : Changlian Zhu; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : hypoxia ischemia; neonatal; cell death; caspase; apoptosis-inducing factor; brain; apoptosis; autophagy; nitric oxide;

    Abstract : Aims: To investigate the mechanisms of neuronal cell death after hypoxia-ischemia in the developing brain.Methods: Rats or mice were subjected to left common carotid artery ligation plus hypoxia. Animals were sacrificed at certain time points after hypoxia-ischemia. READ MORE

  4. 4. Tissue Factor regulation, signaling and functions beyond coagulation with a focus on diabetes

    Author : Desireé Edén; Agneta Siegbahn; Sofia Ramström; Uppsala universitet; []
    Keywords : Tissue factor; diabetes; cell signaling; coagulation; beta cells; adipocytes; apoptosis; lipolysis; micro RNA; Medicinsk vetenskap; Medical Science;

    Abstract : Background: Tissue factor (TF) is a 47 kDa transmembrane glycoprotein best known for initiating the coagulation cascade upon binding of its ligand FVIIa. Apart from its physiological role in coagulation, TF and TF/FVIIa signaling has proved to be involved in diseases such as diabetes, cancer and cardiovascular diseases. READ MORE

  5. 5. Caspase activation in human neuroblastoma cells: mechanisms and spatiotemporal aspects

    Author : Elena V. Ivanova; Kerstin Iverfeldt; Boris Zhivotovsky; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; apoptosis; caspase; local caspase activation; neurodegeneration; tau-anchored FRET sensors; tAFS; cancer; neuroblastoma; TNF-related apoptosis inducing ligand; TRAIL; protein kinase C; PKC; X-linked inhibitor of apoptosis protein; XIAP; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Apoptosis is one of the modes of programmed cell death, in which several members of the caspase family of proteases play the central role. However, activation of apoptotic caspases does not necessarily lead to cell death. READ MORE