Search for dissertations about: "apoptosis."

Showing result 21 - 25 of 1113 swedish dissertations containing the word apoptosis..

  1. 21. ADP regulation of insulin secretion and beta-cell apoptosis

    Author : Chanyuan Tan; Kardiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; P2Y; β-cell; ADP; insulin; apoptosis; autocrine; ectonucleotidase;

    Abstract : The aims of this dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) through ectonucleotidase or ATP release under the effect of high glucose. The expression of the ADP receptors P2Y1 and P2Y13 were shown in both mouse pancreatic islets and isolated β-cells using real-time PCR quantification. READ MORE

  2. 22. UVA/B induced redox alterations and apoptosis in human melanocytes

    Author : Petra Wäster Larsson; Inger Rosdahl; Karin Öllinger; Ian Cotgreave; Linköpings universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; UV; melanocyte; apoptosis; glutathione; p53; Dermatology and venerology; Dermatologi och venerologi;

    Abstract : Malignant melanoma is one of the most rapidly increasing cancers and accounts for about three-quarter of all skin cancer deaths worldwide. Despite compelling evidence that ultraviolet (UV) irradiation causes melanoma the knowledge how various wavelength spectra affect the balance between proliferation and apoptosis controlling the homeostasis of the melanocyte population is still limited. READ MORE

  3. 23. Granulosa cell apoptosis: Transcriptional regulation by the nuclear progesterone receptor

    Author : P. Anders Friberg; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : ovary; granulosa cells; ovulation; luteinization; progesterone; apoptosis; cholesterol synthesis; isoprenylation;

    Abstract : Ovarian follicle atresia caused by granulosa cell apoptosis is a central process in normal female physiology. Progesterone has been reported to be a survival factor in granulosa cells at several developmental stages. READ MORE

  4. 24. Regulation of apoptosis and steroidogenesis in ovarian preovulatory granulosa cells

    Author : Eva Svensson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; granulosa cells; luteinizing hormone; progesterone receptor; RU 486; Org 31710; leptin; steroidogenesis;

    Abstract : Only a minute fraction of ovarian follicles present in a foetal ovary will complete the path to ovulation. The majority of the follicles will instead undergo atresia, a hormonally controlled apoptotic process. Apoptosis occurs throughout follicle development, with an extensive reduction in the number of follicles present at birth. READ MORE

  5. 25. Localisation of Protein Kinase C in Apoptosis and Neurite Outgrowth

    Author : Anna Schultz; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; Medicine human and vertebrates ; Medicin människa och djur ; Cytology; oncology; cancerology; Cytologi; Prostate Cancer; Neuroblastoma; Ceramide; Golgi Apparatus; Neurite outgrowth; Apoptosis; Protein Kinase C; C1 domain;

    Abstract : Protein kinase C (PKC) is a family of serine/threonine kinases, which are subgrouped into classical (a, bI, bII, g), novel (d, e, h, q) and atypical (z, i/l) isoforms. One major aim of this thesis work was to investigate if altered levels of PKC isoforms influence the apoptotic responses of malignant cell-lines. READ MORE