Search for dissertations about: "apoptosis"

Showing result 6 - 10 of 1200 swedish dissertations containing the word apoptosis.

  2. 6. Radiation-induced apoptosis in human lymphocytes : studies on expression, function and effects of different radiation qualities

    Author : Annelie Meijer; Fabrizio Palitti; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Apoptosis; clonogenic survival; growth factors; chromosomal aberrations CA ; low dose-rate LDR ; linear energy transfer LET ; relative biological effectiveness RBE ; radio sensitivity; ataxia telangiectasia A-T ; Physical Biology; fysikalisk biologi;

    Abstract : We are constantly exposed to radiation. Radiation causes damage to our cells. By the removal of damaged and unwanted cells, apoptosis is considered to be one of the most indispensable defence processes for a multi-cellular organism. READ MORE

  4. 7. p38 MAPK Signalling in Endothelial Apoptosis

    Author : Simone Grethe; Malmö Experimentell patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Naturvetenskap; Natural science; PP2A; Bad; Bcl-xL; doxorubicin; TNF; p38 MAPK; Apoptosis; endothelial cells;

    Abstract : Endothelial apoptosis plays an important role in atherosclerosis, and a direct proapoptotic effect of chemotherapeutics on the tumour vasculature, emphasizes the great potency of antiangiogenic therapy in the treatment of cancer. We investigated signalling pathways in endothelial apoptosis induced by the inflammatory cytokine tumour necrosis factor alpha (TNF), the main target of which is the endothelium, and by the anticancer drug doxorubicin. READ MORE

  5. 8. Apoptosis Regulation via the Mitochondrial Pathway : Membrane Response upon Apoptotic Stimuli

    Author : Marc-Antoine Sani; Gerhard Grobner; Antoinette Killian; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Apoptosis; BH4 peptide; Bax-α1 peptide; model membrane; cardiolipin; solid phase peptide synthesis; circular dichroism; solid-state nuclear magnetic resonance spectroscopy.; Biophysics; Biofysik;

    Abstract : The aim of this thesis was the investigation of the mitochondrial response mechanisms upon apoptotic stimuli. The specific objectives were the biophysical characterization of membrane dynamics and the specific roles of lipids in the context of apoptotic regulation occurring at the mitochondrion and its complex membrane systems. READ MORE

  6. 9. Palmitate-induced Apoptosis in Insulin-producing β-cells

    Author : Kristofer Thörn; Peter Bergsten; Claes Wollheim; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ER stress; apoptosis; palmitate; sphingosine-1-phosphate; ceramide; beta-cell; fatty acid; Medical cell biology; Medicinsk cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Type 2 diabetes is a disease characterized by the inability of pancreatic β-cells to secrete sufficient amounts of insulin to maintain normoglycemia. Increased levels of saturated fatty acids such as palmitate are believed to contribute to β-cell failure and the development of the disease. READ MORE

  7. 10. Regulation of apoptosis in the thyroid epithelium

    Author : Abeba Demelash; Göteborgs universitet; []
    Keywords : Thyroid; Apoptosis; Caspase; Calpain; Hydrogen peroxide; TGF-beta; Staurosporine; Selenium; Cytochrome c;

    Abstract : Apoptosis or programmed cell death allows the multicellular organism to remove cells that are in excess or potentially dangerous. Apoptosis has to be strictly controlled, yet inappropriately activated or suppressed apoptototic may contribute to a variety of diseases, including cancer, autoimmune disorders and neurodegenerative conditions. READ MORE