Search for dissertations about: "aptamer"

Showing result 1 - 5 of 9 swedish dissertations containing the word aptamer.

2. 1. Strategies for Miniaturized Biomarker Detection

   Author : Belinda Adler; Avdelningen för Biomedicinsk teknik; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; biomarker; miniturization; lab-on-a-chip; proteomics; PSA; microarray; mass spectrometry; MALDI MS; SPE; sample preparation; immunoaffinity; antibody; aptamer; mass tag; ISET.;

   Abstract : The aim of this thesis is development and application of different miniaturized strategies for detection of biomarkers. The biomarker PSA (prostate specific antigen), which is prostate cancer specific, has been the main focus of the thesis. READ MORE

4. 2. Proximity Ligation as a Universal Protein Detection Tool

   Author : Mats Gullberg; Charles Cantor; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular medicine; Proximity ligation; proteomics; aptamer; antibody; molecular beacon; rolling circle amplification; Molekylärmedicin; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Molekylär medicin; Molecular Medicine;

   Abstract : Among the great challenges in biology are the precise quantification of specific sets of proteins and analyses of their patterns of interaction on a much larger scale than is possible today.This thesis presents a novel protein detection technique - proximity ligation - and reports the development and application of a nucleic acid amplification technique, RCA. READ MORE

5. 3. Gene targeting and delivery of therapeutic oligonucleotides

   Author : Olof Gissberg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Research in gene therapeutic strategies involving oligonucleotides (ONs) constitutes a growing field with several clinical products already approved and many more under intense investigation. The recent advances have mainly involved the Antisense ON platform, with the aim of modulating gene expression on the RNA level. READ MORE

6. 4. Interface Studies for Gold-based Electrochemical DNA Sensors

   Author : Xingxing Xu; Zhen Zhang; Boukherroub Rabah; Uppsala universitet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

   Abstract : Gold based label-free electrochemical DNA sensors have been widely studied for biomarker diagnostics. The sensitivity and reproducibility of these sensors are determined by the sensing interface: the DNA modified gold surfaces. READ MORE

7. 5. Organic Bioelectronic Devices for Selective Biomarker Sensing : Towards Integration with Living Systems

   Author : Chiara Diacci; Magnus Berggren; Daniel Simon; Francesca Santoro; Linköpings universitet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

   Abstract : Inorganic materials have been the main players of the semiconductor industry for the past forty years. However, there has been a continuous interest and growth in the research and in the application of organic semiconductors (OSCs) as active materials in electronic devices, due to the possibility to process these materials at low temperature on flexible substrates, fabricate them on large-area, and upscale their fabrication using cost-effective strategies such as printing. READ MORE