Search for dissertations about: "arachidonic acid"

Showing result 11 - 15 of 115 swedish dissertations containing the words arachidonic acid.

  2. 11. The involvement of calcium and membrane fusion events in neutrophil secretion and respiratory burst

    Author : Daniel Granfeldt; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophils; calcium; regulated secretion; membrane fusion; SOC; arachidonic acid; intracellular fusion; oxygen free radicals; phagocytosis;

    Abstract : Neutrophil granulocytes play an important role in host defence during the early stages of microbial infection. The neutrophils have to leave the blood stream and migrate out into the tissue where they are able to phagocytose and kill microbes as well as dispose of cell debris from damaged tissues. READ MORE

  4. 12. Studies on arachidonic acid metabolism in normal and malignant hematopoietic cells

    Author : Stina Feltenmark; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis deals with the metabolism of arachidonic acid via the 5-lipoxygenase- and the 15-lipoxygenase-1 pathways in normal and malignant hematopoietic cells. The first part of the thesis (papers I & II) describes the expression of genes involved in arachidonic acid metabolism and the capacity to generate leukotriene (LT) B4 via the 5-lipoxygenase pathway in blood tumor cells from patients with precursor B-ALL (acute lymphoblastic leukemia) and AML (acute myeloid leukemia). READ MORE

  5. 13. Cytochrome P450 enzymes in oxygenation of prostaglandin endoperoxides and arachidonic acid : Cloning, expression and catalytic properties of CYP4F8 and CYP4F21

    Author : Johan Bylund; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Abstract : Cytochrome P450 (P450 or CYP) is an enzyme system involved in the oxygenation of a wide range of endogenous compounds as well as foreign chemicals and drugs. This thesis describes investigations of P450-catalyzed oxygenation of prostaglandins, linoleic and arachidoniacids. READ MORE

  6. 14. Identification of arachidonic acid metabolites formed through the 15-lipoxygenase-1 pathway

    Author : Åsa Brunnström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The polyunsaturated fatty acid arachidonic acid is the precursor of many biologically active lipid mediators. This thesis is focused on the arachidonic acid metabolites formed through the 15-lipoxygenase-1 (15-LO-1) pathway. READ MORE

  7. 15. Novel aspects of P-amionbenzoic acid metabolism in connection with arachidonic acid oxidation in human lymphoid cells and platelets

    Author : Bruno Barbieri; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The arachidonic acid metabolites - in particular the prostaglandins, thromboxanes and leukotrienes - have diverse and potent pharmacological effects and may also prove physiologically and pathologically significant. In long term incubation of human peripheral blood mononuclear leukocytes (PBML) in RPMI 1640 with fetal calf serum and [1-14C] arachidonic acid (AA) besides small amounts of some of these known metabolites a radioactive substance with chromatographical behaviour like no known eicosanoid was identified. READ MORE