Search for dissertations about: "archival samples"

Showing result 1 - 5 of 12 swedish dissertations containing the words archival samples.

  2. 1. Usefulness of archival biobank samples for genetic epidemiologic studies

    Author : Malin Sjöholm; Malmö Klinisk mikrobiologi; []
    Keywords : formailn-fixed paraffin-embedded tissue; biobank; serum; dried blood spots; plasma; archival samples;

    Abstract : Sweden has a long history of maintaining population-based registries and biobanks. This has resulted in large sample collections with long follow-up and large numbers of prospectively occurring disease endpoints providing an extensive resource for genetic research. READ MORE

  4. 2. The use of formalin fixed paraffin embedded tissue and global gene expression profiling for increased understanding of squamous cell carcinoma of the tongue

    Author : Rentoft Matilda; Karin Nylander; Michael Prystowsky; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SCCHN; tongue; microarray; DASL; FFPE; archival; mRNA; miRNA; patologi; Pathology;

    Abstract : Head and neck cancer is the 6th most common malignancy worldwide, with tumours of the tongue being one of the most prevalent sites. Despite advances in surgery and radiotherapy, the five-year survival has not changed during the last decades and remains at approximately 50%. READ MORE

  5. 3. Cervical carcinoma in Kampala, Uganda, and the relationship with human immunodeficiency virus and human papillomavirus infections

    Author : Michael Odida; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HPV; Human Papillomaviruses; women; HIV; Uganda; invasive cervical cancer;

    Abstract : Introduction: Cervical carcinoma is the commonest tumour in Ugandan women. However, very little is known in the Ugandan population about HPV types associated with invasive cervical cancer, the relative risk of cervical cancer associated with different HPV types, and whether the risk of cervical cancer associated with HPV infection is modified by HIV infection. READ MORE

  6. 4. Molecular markers reflecting malignant transformation and tumor progression

    Author : Patricia Stoltzfus; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Molecular markers; interphase fluorescence in situ hytidization; genetic diagnostic test; laminin-5 gamma2 chain; immunohistochemistry; precancerous lesions; invasiveness; breast cancer; cervical squamous cell carcinoma; tongue carcinoma; vulvar carcinoma;

    Abstract : The early detection of neoplastic lesions is most critical in the successful treatment of malignant disease. This thesis investigates molecular targets for an improved detection and diagnosis of cancer by exploring the value of interphase fluorescence in situ hybridization (FISH) to detect specific chromosomal aneuploidies and gene amplifications, and laminin-5 gamma2 chain expression detected by immunohistochemistry as a marker for invasiveness. READ MORE

  7. 5. Application of the Fluoresecence Lidar Techniques in the Architectural Heritage

    Author : Jenny Hällström; Bebyggelsevård; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; architectural heritage; stone; brick; conservation; restoration; case studies; building investigation; lidar; fluorescence; laser; masonry;

    Abstract : The primary aim of the research project is to analyse the potential for the application of lidar and fluorescence techniques in building investigation, and also to establish a scientific remote-sensing method for surveying and analysing the historical facade that is non-destructive and can be used in-situ. The fluorescence lidar method uses point-monitoring and scanning of areas that can provide multispectral images in order to identify materials, biodeteriogens and other substances not visible to the human eye. READ MORE