Search for dissertations about: "arsenic resistance"
Showing result 1 - 5 of 13 swedish dissertations containing the words arsenic resistance.
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1. Prokaryotic Arsenic Resistance - Studies in Bacillus subtilis
Abstract : Arsenic is a toxic metalloid which is found all over the globe. Due to its toxicity and wide abundance, all living organisms have evolved intrinsic arsenic resistance systems. In this study, three proteins that provide arsenic resistance in the Gram-positive bacterium Bacillus subtilis have been investigated. READ MORE
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2. Arsenic-induced protein aggregation and toxicity in Saccharomyces cerevisiae
Abstract : Arsenic is prevalent in the environment and this toxic metalloid poses a substantial threat to human health with 100-200 million people worldwide estimated to be at risk. Chronic exposure to arsenic is associated with neurodegenerative and age-related disorders that are characterized by the accumulation of protein aggregates, including Parkinson’s and Alzheimer’s disease. READ MORE
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3. Effects of arsenic trioxide and hypoxia in multidrug-resistant neuroblastoma
Abstract : Neuroblastoma is a childhood tumour derived from the sympathetic nervous system. Although most children with neuroblastoma initially respond to treatment, approximately 50% of these patients relapse with multidrug-resistant tumours. Arsenic trioxide (As2O3) has been used for centuries to treat different clinical disorders including malignancies. READ MORE
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4. Approaches to Treatment of Children with Advanced Neuroblastoma
Abstract : Children with advanced neuroblastoma are at high risk for relapse of multidrug resistant disease, despite initial response to intensive multimodality treatment. Neuroblastomas have similarities with immature neuroblasts seen during embryonic development of the sympathetic nervous system (the origin of these tumors). READ MORE
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5. Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma
Abstract : Small cell lung carcinoma (SCLC) is a very aggressive solid tumor and is often widely metastasized by the time of diagnosis. Despite good response to the initial chemotherapy, SCLC cells often develop multidrug resistance to conventionally used chemotherapeutic drugs, which cause almost all SCLC tumors to relapse. READ MORE