Search for dissertations about: "artemisinins"

Showing result 1 - 5 of 6 swedish dissertations containing the word artemisinins.

  2. 1. Clinical pharmacokinetics and pharmacodynamics of antimalarial combination therapy

    Author : Sofia Friberg Hietala; Göteborgs universitet; []
    Keywords : pharmacokinetics; pharmacodynamics; antimalarials; artemisinins;

    Abstract : In the face of growing drug resistance, the World Health Organization (WHO) has issued recommendations strongly encouraging the use of combination therapies to combat uncomplicated malaria. Amongst the most effective treatments are those combining an artemisinin derivative with a longer acting component such as amodiaquine, lumefantrine or piperaquine. READ MORE

  4. 2. Experimental pharmacodynamic and kinetic studies related to new combination therapies against P. falciparum malaria

    Author : Seema Gupta; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Artemisinin (ART) class of compounds are of special interest due to their rapid onset of action and high activity against multidrug resistant malaria. The major drawback in monotherapy with ART and its derivatives is the high rate of recrudescent infection. READ MORE

  5. 3. Pharmacokinetics, drug metabolism and clinical effects of the antimalarial artemisinin : Time-dependencies and modeling aspects

    Author : Ulrika Sigrid Helena Svensson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; Biofarmaci;

    Abstract : The mechanism behind artemisinin time-dependent bioavailability was investigated using a rat in-situ single-pass jejunal perfusion technique. The consequence for drug combination therapy was studied in healthy volunteers and in patients with Plasmodium falciparum. READ MORE

  6. 4. Molecular basis for the mechanism of action and resistance to artemisinin combination therapy in Plasmodium falciparum

    Author : Pedro Ferreira; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Plasmodium falciparum;

    Abstract : Malaria, caused by the Plasmodium falciparum parasite, remains a leading cause of death among children in Africa. To improve treatment efficacy and delay development and spread of antimalarial drug resistance artemisinin artemisinin-based combination therapy (ACT) is now globally recommended as first-line treatment of uncomplicated P. READ MORE

  7. 5. The molecular basis of Plasmodium falciparum resistance to the antimalarial lumefantrine

    Author : Christin Sisowath; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Malaria control is compromised by the development and spread of Plasmodium falciparum resistance to antimalarial drugs, which has caused an increase in malaria related morbidity and mortality. Artemisinin based combination therapy (ACT) has been implemented in almost all malaria endemic areas in an attempt to suppress drug resistance. READ MORE