Search for dissertations about: "aryl hydrocarbon receptor"

Showing result 1 - 5 of 38 swedish dissertations containing the words aryl hydrocarbon receptor.

  1. 1. Estrogen and aryl hydrocarbon receptor signaling

    Author : Elin Swedenborg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : The biological effects of estrogens are mediated by the two estrogen receptor (ER) isoforms, ERa and ERb. The ERs are ligand-inducible transcription factors that belong to the nuclear receptor (NR) superfamily. Ligand-activated ERs bind to specific DNA elements in promoters of target genes, thereby inducing transcription. READ MORE

  2. 2. Computational methods for analyzing dioxin-like compounds and identifying potential aryl hydrocarbon receptor ligands : multivariate studies based on human and rodent in vitro data

    Author : Malin Larsson; Patrik Andersson; Anna Linusson; Mats Tysklind; Scott Boyer; Umeå universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; dioxin-like compounds; multivariate analysis; toxic equivalency factor; quantitative structure-activity relationship; descriptors; virtual screening; in vitro; species variation; aryl hydrocarbon receptor;

    Abstract : Polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) are omnipresent and persistent environmental pollutants. In particular, 29 congeners are of special concern, and these are usually referred to as dioxin-like compounds (DLCs). READ MORE

  3. 3. Genetic, environmental and life-style effects on androgen receptor function

    Author : Christel Björk; Malmö Molekylärgenetisk reproduktionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reproductive function; smoking; 4 .4-DDE; persistent organic pollutants; prostate cancer; Androgen receptor; prostate specific antigen; CAG polymorphism; TCDD; aryl hydrocarbon receptor; CB-153;

    Abstract : Androgens regulate male reproductive function and their effects are mediated through the androgen receptor (AR). The AR gene contains a polymorphic CAG repeat, encoding a stretch of glutamines, affecting the transcriptional activity of the AR. READ MORE

  4. 4. Influence of oxidative stress on aryl hydrocarbon receptor signaling

    Author : Afshin Mohammadi Bardbori; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : The aryl hydrocarbon receptor (AHR), a multifunctional protein and a key regulator of drug metabolizing enzymes, belongs to the basic-helix-loop-helix (bHLH)/PAS (Per- Arnt-Sim) super-family of transcription factors. The AHR responds to exogenous and endogenous chemicals by induction or repression of a large number of genes involved in many physiological processes and normal development. READ MORE

  5. 5. Synthesis of indoles, bisindoles and indolocarbazoles : High affinity aryl hydrocarbon receptor ligands

    Author : Niklas Wahlström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Indole; bisindoles; carbazole; indolocarbazole; indolo[3; 2-b]carbazole; ICZ; FICZ; alkaloid; metabolite; tropolone; caulersin; aryl hydrocarbon receptor; Ali receptor; X-ray crystallography; Lewis acid; acylation; Vilsmeier reaction.;

    Abstract : This thesis deals with the synthesis and reactions of indoles, bisindoles, indolocarbazoles and their derivatives. New methods for ring formation of planar, heterocyclic quinones, with the indolo[3,2b]carbazole or indolo[2,3-b]carbazole structures are described. READ MORE