Search for dissertations about: "aryl hydrocarbon receptor"
Showing result 6 - 10 of 40 swedish dissertations containing the words aryl hydrocarbon receptor.
-
6. The impact of cytochrome P4501-inhibitors on aryl hydrocarbon receptor signaling
Abstract : The aryl hydrocarbon receptor (AHR) best known as a ligand-activated transcription factor that mediates toxic responses to xenobiotics such as dioxins, is also activated by certain endogenous compounds. Activation of the AHR up-regulates transcription of a large number of genes, including those encoding members of the cytochrome P450 1 family of enzymes (CYP1s). READ MORE
-
7. Dynamic regulation of aryl hydrocarbon receptor function and activity by different stimuli
Abstract : Cells have to sense and adapt to changes in their surrounding environment. Most of the cellular responses to environmental and developmental stimuli are mediated by PAS (Per-ARNT-Sim) proteins. A member of this family of proteins is the aryl hydrocarbon receptor (AhR), a ligand-activated bHLH transcription factor and E3 ubiquitin ligase. READ MORE
-
8. Bioassay analysis of dioxin-like compounds : response interactions and environmental transformation of Ah receptor agonists
Abstract : Dioxin-like compounds mediate their toxicity by binding to the aryl hydrocarbon receptor (AhR) and through this receptor a cascade of biochemical and toxic events are triggered. Mechanism-specific dioxin bioassays utilise the AhR coupled induction of endogenous CYP1A proteins or reporter gene systems for detection of dioxin-like compounds and other AhR ligands. READ MORE
-
9. Mechanisms of activation of the aryl hydrocarbon receptor by novel inducers of the CYP1A1 gene
Abstract : The aryl hydrocarbon receptor (AhR) functions as a ligand-activated transcription factor that is responsible for the activation of several response genes, of which the best characterised is the CYP1A1 gene. The prototype high affinity ligand for the AhR is the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). READ MORE
-
10. Body constitution, statin use, and tumor characteristics. Implications for prognosis
Abstract : Breast cancer is an important cause of disease-burden and death in women. To prevent over- and undertreatment of breast cancer patients, new prognostic and predictive factors are needed. READ MORE