Search for dissertations about: "aryl ketones"

Showing result 1 - 5 of 25 swedish dissertations containing the words aryl ketones.

2. 1. Palladium(II)-Catalyzed Addition Reactions : Synthesis of Aryl Amidines and Aryl Ketones

   Author : Jonas Rydfjord; Mats Larhed; Adriaan Minnaard; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Palladium; Catalysis; Palladium II catalysis; Synthesis; Addition Reactions; Cyanamide; Amidine; Aryl Amidine; Nitrile; Ketone; Aryl Ketone; Carbopalladation; Continuous-flow; Continuous flow; Microwave heating; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Palladium-catalyzed reactions have become one of the most important tools in modern organic chemistry due to its ability to catalyze the formation of new carbon-carbon bonds.The aim of the work presented in this thesis was to develop new palladium(II)-catalyzed addition reactions. READ MORE

4. 2. Development of HIV-1 Protease Inhibitors and Palladium-Catalyzed Synthesis of Aryl Ketones and N-Allylbenzamides

   Author : Linda Axelsson; Mats Larhed; Anders Karlén; Luke Odell; Morten Grötli; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; palladium; aminocarbonylation; aryl ketones; decarboxylation; HIV; protease inhibitor; tertiary alcohol; macrocycles; Medicinal Chemistry; Läkemedelskemi;

   Abstract : The use of palladium-catalyzed reactions to introduce new carbon-carbon bonds is a fundamental synthetic strategy that has been widely embraced due to its high chemo- and regioselectivity and functional group tolerance. In this context, Pd(0)-catalyzed aminocarbonylations using Mo(CO)6 instead of toxic and gaseous CO and with allylamine as the nucleophile were investigated. READ MORE

5. 3. Palladium-Catalyzed Carbonylation and Arylation Reactions

   Author : Jonas Sävmarker; Mats Larhed; Gary Molander; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; palladium; carbonylation; styrene; amidine; aryl ketones; aryl sulfinates; ESI-MS; aryltrifluoroborates; Organic Pharmaceutical Chemistry; Organisk farmaceutisk kemi;

   Abstract : Palladium-catalyzed reactions have found widespread use in contemporary organic chemistry due to their impressive range of functional group tolerance and high chemo- and regioselectivity. The pioneering contributions to the development of the Pd-catalyzed C-C bond forming cross-coupling reaction were rewarded with the Nobel Prize in Chemistry in 2010. READ MORE

6. 4. Asymmetric transfer hydrogenation of ketones : Catalyst development and mechanistic investigation

   Author : Katrin Ahlford; Hans Adolfsson; Martin Wills; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Asymmetric catalysis; reduction; amino acid; rhodium; mechanistic investigation; kinetic study; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Abstract : The development of ligands derived from natural amino acids for asymmetric transfer hydrogenation (ATH) of prochiral ketones is described herein. In the first part, reductions performed in alcoholic media are examined, where it is found that amino acid-derived hydroxamic acids and thioamides, respectively, are simple and versatile ligands that in combination with [RhCp*Cl2]2 efficiently catalyze this particular transformation. READ MORE

7. 5. Palladium(II)-Catalyzed Coupling Reactions

   Author : Jonas Lindh; Mats Larhed; Matthew S. Sigman; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Palladium II ; oxidative Heck reactions; Microwaves; Styrenes; Aryl ketones; Continuous flow; ESI-MS; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; Läkemedelskemi;

   Abstract : Sustainable chemical processes are becoming increasingly important in all fields of synthetic chemistry. Catalysis can play an important role in developing environmentally benign chemical processes, and transition metals have an important role to play in the area of green chemistry. READ MORE