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Showing result 1 - 5 of 30 swedish dissertations matching the above criteria.
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1. Cancer Evolution under Chemotherapy Treatment
Abstract : Background: Chemotherapy resistance is a critical issue in oncology, being responsible for the majority of deaths in modern cancer care. My PhD work has focused on two cancer types where such drug resistance is a major clinical issue: epithelial ovarian cancer (EOC) and Wilms tumor (WT). READ MORE
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2. The release of histone proteins from cells via extracellular vesicles
Abstract : Histones are chromatin-associated proteins localized to the nucleus. However, extracellular histones are present in biofluids from healthy individuals and become elevated under disease conditions, such as neurodegeneration and cancer. READ MORE
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3. Studies on a polypeptide inhibiting cell growth obtained from human ascites tumour fluid
Abstract : .... READ MORE
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4. Demonstration and characterization of ecto-sialyltransferase in surface membranes of intact Ehrlich ascites tumour cells
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5. p53 inactivation by point mutations and splice site mutations in human and mouse tumors
Abstract : The p53 tumor suppressor gene is frequently mutated in human tumors. p53 induces cell cycle arrest and/or apoptosis in response to cellular stress, such as DNA damage, hypoxia and certain activated oncogenes like c-myc. The status of p53 in Burkitt's Iymphoma (BL) cell lines was investigated. The majority of BL lines expressed mutated p53 protein. READ MORE