Search for dissertations about: "assay DEVELOPMENT"

Showing result 1 - 5 of 594 swedish dissertations containing the words assay DEVELOPMENT.

  2. 1. Proximity Extension Assay : a universal tool for proteomics in precision medicine

    Author : Phathutshedzo M. Muthelo; Ulf Landegren; Jochen Schwenk; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proximity Extension Assay; Precision medicine; Assay development; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : Precision medicine aims to utilise biomarkers to ensure the right treatment is given to the right patient at the right time. In pursuit of this goal, sensitive protein detection is essential to improve opportunities for discovery, verification, validation and development of valuable protein biomarkers. READ MORE

  4. 2. Programmed Cell Death in Xylem Development

    Author : Laetitia Charleen Courtois-Moreau; Hannele Tuominen; Stefan Jansson; Christina Dixelius; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PCD Programmed Cell Death ; Xylem; Apoptosis; Autophagy; Secondary Cell Walls; Microscopy; Microarrays; Comet Assay; TUNEL Assay; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : Concerns about climate changes and scarcity of fossil fuels are rising. Hence wood is becoming an attractive source of renewable energy and raw material and these new dimensions have prompted increasing interest in wood formation in trees, in both the scientific community and wider public. READ MORE

  5. 3. A Gill Filament EROD Assay : Development and Application in Environmental Monitoring

    Author : Maria Jönsson; Ingvar Brandt; Björn Brunström; Kristian Ingebrigtsen; Håkan Olsén; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; aquatic; benzo[a]pyrene; biomarker; CYP1A; environmental monitoring; EROD; fish; gill; indigo; PCB; Biologi; Biology; Biologi;

    Abstract : A gill filament-based assay for the cytochrome P450 1A (CYP1A)-catalysed activity ethoxyresorufin O-deethylase (EROD) was developed in rainbow trout (Oncorhynchus mykiss) and applied to Atlantic salmon (Salmo salar), Arctic charr (Salvelinus alpinus), Atlantic cod (Gadus morhua), saithe (Pollachius virens), and spotted wolffish (Anarhichas minor). Exposure to waterborne β-naphthoflavone (βNF; 10-6 M) induced branchial EROD activity in all species but the spotted wolffish. READ MORE

  6. 4. Evolving the Methodology for Detection of Primary DNA Damage : Development, adaptation and assessment of the single cell gel electrophoresis (comet) assay

    Author : Erik Bivehed; Björn Hellman; Hanna Karlsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Comet assay; DNA damage; DNA strand breaks; Flash-comet; Genotoxicity; In vitro; Single cell gel electrophoresis; Polymerase assisted DNA damage assay PADDA ; TK6 cells; UCDAS; U937 cells; Toxikologi; Toxicology; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Deoxyribonucleic acid (DNA) is one of the most important molecules in nature. It is the fundamental carrier of evolutionary information and constitutes the genetic blueprint of all living organisms. Being the sole source of information, it is vital for the cell to transmit the correct genetic information from generation to generation. READ MORE

  7. 5. Gene therapy tools: oligonucleotides and peptides

    Author : Jonas Eriksson; Ülo Langel; Jens Kurreck; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Gene therapy; oligonucleotide; peptide; RNA-cleaving deoxyribozyme; deoxyribozyme; DNAzyme; cell-penetrating peptide; CPP; enzyme; enzyme kinetics; kinetic assay; assay; telomerase; telomerase inhibitor; imetelstat; GRN163L; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Genetic mutations can cause a wide range of diseases, e.g. cancer. Gene therapy has the potential to alleviate or even cure these diseases. READ MORE