Search for dissertations about: "association mapping"
Showing result 31 - 35 of 127 swedish dissertations containing the words association mapping.
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31. The genetics of systemic lupus erythematosus : Mapping of susceptibility loci for human SLE
Abstract : Systemic lupus erythematosus (SLE) is a systemic autoimmune disease affecting organs such as skin, jointsand kidneys. Characteristic for the disease is increased production of autoantibodies, in particular against dsDNA. Previous studies of SLE in mouse models and in humans indicate polygenic inheritance and genetic heterogeneity. READ MORE
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32. Gene mapping of reproduction traits in dairy cattle
Abstract : In this thesis my aims were to map genes affecting reproduction in cattle and to explore the correlated effect of these genes on yield traits. This knowledge is expected to provide novel insights into the biological processes underlying reproduction traits and to identify individual causal polymorphisms or genetic markers for practical application in marker-assisted and genomic selection strategies. READ MORE
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33. Population level genome-wide association studies in dairy cattle
Abstract : In recent years, genome-wide association studies (GWAS) has become a dominant tool for detecting genetic architectures for complex traits. Thousands of associated genetic variants have been reported. However, the resolution of these studies was limited by the available marker density for the quantitative trait loci (QTL) region. READ MORE
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34. Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
Abstract : To gain insight into the importance of the genome for diseases, sequencing and genotyping efforts aim to identify the consequences of genetic variation on both a functional and population level. The task involves the fine-resolution mapping of biologically significant genes and regions discerned by linkage analysis. READ MORE
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35. Genetic Studies of Psoriasis and Psoriatic Arthritis
Abstract : Psoriasis and psoriatic arthritis are common chronic immune-mediated diseases of the skin and joints. Psoriasis affects approximately 2-3 % of the Caucasian population and about 30 % of all psoriasis patients develop psoriatic arthritis. READ MORE