Search for dissertations about: "astrocytoma"

Showing result 16 - 20 of 24 swedish dissertations containing the word astrocytoma.

  2. 16. Functional studies of the Quaking gene : Focus on astroglia and neurodevelopment

    Author : Katarzyna Radomska; Elena Jazin; Pertti Panula; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; QKI; RNA-binding protein; astrocyte; interferon; GFAP; neurodevelopment; zebrafish; neural progenitor cell;

    Abstract : The RNA-binding protein Quaking (QKI) plays a fundamental role in post-transcriptional gene regulation during mammalian nervous system development. QKI is well known for advancing oligodendroglia differentiation and myelination, however, its functions in astrocytes and embryonic central nervous system (CNS) development remain poorly understood. READ MORE

  4. 17. lmproving diagnosis of central nervous system tumours using genetic and epigenetic tools

    Author : Thomas Olsson Bontell; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Histopathology; DNA methylation profiling; DNA methylation-based classification; Diffuse lower grade-glioma; Genomic analysis; Molecular biomarkers; Pediatric glioma;

    Abstract : Brain tumor diagnostics has traditionally been based on histopathology stains. The introduction of immunohistochemistry stains resulted in improved ability to classify these often devastating tumors. The understanding of molecular markers in central nervous system tumors has improved substantially in recent decades. READ MORE

  5. 18. Roles of the transient receptor potential channels and the intracellular Ca2+ channels in Ca2+ signaling in the beta-cells

    Author : Amanda Jabin Fågelskiöld; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Ca2 signaling;

    Abstract : Previous studies from our group reported that pancreatic β-cells express ryanodine receptors (RyRs) that can mediate Ca2+-induced Ca2+ release (CICR). The full consequences of the activation of RyRs on Ca2+ signaling in these cells, however, remained unclear. READ MORE

  6. 19. Neural Progenitor Cells in malignancy and injury of the brain. A Trojan Horse fro gliomas?

    Author : Karin Staflin; CNS Genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serologi; transplantation; Immunologi; Medicine human and vertebrates ; Medicin människa och djur ; Immunology; serology; Glioma; sub ventricular zone; neural progenitor cell;

    Abstract : Gliomas are neoplasms arising in the central nervous system (CNS), and constitute the most common primary brain tumor. They are classified depending on the grade and morphology, from grade I, pilocytic astrocytoma, to grade IV, glioblastoma multiforme (GBM). Glioblastomas constitute a great challenge in treatment due to their disseminating nature. READ MORE

  7. 20. Molecular studies of the insulin-like growth factor system in the brain : focus on growth, tumorigenesis and trauma

    Author : Ann-Christin Sandberg Nordqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : insulin-like growth factors; insulin-like growth factor binding proteins; brain; mRNA; meningioma; glioma; traumatic brain injury; in situ hybridization; Northern blothybridization;

    Abstract : Insulin-like growth factor (IGF) 1 and -2 are synthesized by most tissues of the body and function as autocrine or paracrine agents in a tissue-specific manner. mRNA for IGF-1 and -2, as well as the IGF-binding proteins, are synthesized locally in various regions of the brain. READ MORE