Search for dissertations about: "ataxia telangiectasia A-T"

Found 3 swedish dissertations containing the words ataxia telangiectasia A-T.

  2. 1. Radiation-induced apoptosis in human lymphocytes : studies on expression, function and effects of different radiation qualities

    Author : Annelie Meijer; Fabrizio Palitti; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Apoptosis; clonogenic survival; growth factors; chromosomal aberrations CA ; low dose-rate LDR ; linear energy transfer LET ; relative biological effectiveness RBE ; radio sensitivity; ataxia telangiectasia A-T ; Physical Biology; fysikalisk biologi;

    Abstract : We are constantly exposed to radiation. Radiation causes damage to our cells. By the removal of damaged and unwanted cells, apoptosis is considered to be one of the most indispensable defence processes for a multi-cellular organism. READ MORE

  4. 2. Functional analysis of ATM with relevance for primary immunodeficiency and tumor formation

    Author : Aleksi Lähdesmäki; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by cerebellar degeneration with ataxia, ocular and cutaneous telangiectasias, radiosensitivity, chromosomal instability, immunodeficiency, and cancer predisposition in both patients and heterozygous carriers of the gene. The gene responsible for the disorder, ATM, has been identified as a member of a family of phosphatidylinositol 3-kinaserelated genes and is one of the master controllers of the networks that are involved in cell cycle control and response to DNA damage. READ MORE

  5. 3. Role of DNA repair in class switch recombination and somatic hypermutation

    Author : Likun Du; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Class switch recombination (CSR) and somatic hypermutation (SHM), occurring in the germinal center, are two important processes for B cell development. Both are initiated by activation-induced cytidine deaminase (AID), through deamination of the C residues in the variable and switch regions of the immunoglobulin locus, resulting in either in single stranded or double stranded DNA breaks. READ MORE