Search for dissertations about: "autoantigen"
Showing result 16 - 20 of 65 swedish dissertations containing the word autoantigen.
-
16. Physiology and Pathophysiology of Hormone Secretion from lslets of Langerhans
Abstract : Diabetes is a metabolic disorder stemming from the improper regulation of blood glucose levels by hormones secreted by pancreatic islets of Langerhans. Paper I describes the mechanism by which glucose can regulate glucagon secretion, independent of membrane potential, from pancreatic α-cells, via modulation of endoplasmic reticulum Ca2+ handling. READ MORE
-
17. Function and Regulation of B-cell Subsets in Experimental Autoimmune Arthritis
Abstract : B lymphocytes play a significant role in autoimmune arthritis, with their function stretching beyond autoantibody production to cytokine secretion and presentation of autoantigen. However, the involvement and activation of different B-cell subset in the autoimmune response is not fully clear. READ MORE
-
18. Biomarker Discovery in Tissue-specific Autoimmune Disease
Abstract : Autoimmune diseases encompass a diverse group of disorders that collectively affect 5% of the population. Despite large clinical variability, autoimmune disorders share a common etiology in that they all develop from immune responses against self. READ MORE
-
19. TRIM21/ Ro52 in B cell pathology
Abstract : Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease affecting 0.2% of the population. Several B cell aberrances have been linked to pSS, such as autoantibody production, hypergammaglobulinemia and B cell associated genetic polymorphisms. In addition, pSS patients display a 16 fold increased risk to develop B cell lymphomas. READ MORE
-
20. Ro52 antibodies and susceptibility genes in congenital heart block
Abstract : Congenital heart block (CHB) develops in fetuses of Ro/SSA and La/SSB positive women. During pregnancy, the autoantibodies cross the placenta and affect the fetus in which a potentially lethal atrioventricular (AV) block may develop. READ MORE