Search for dissertations about: "autocrine signalling"

Showing result 1 - 5 of 20 swedish dissertations containing the words autocrine signalling.

  2. 1. Effects of cytokines on preadipocyte differentiation and Wnt signalling

    Author : Birgit Gustafson; Göteborgs universitet; []
    Keywords : adipocyte differentiation; adiponectin; beta-Catenin; C EBPalpha; IL-6; PPARgamma; TNFalpha; Wnt signalling;

    Abstract : The relationship between amount of adipose tissue, the Metabolic Syndrome and Type 2 diabetes has been recognized for several years. However, the mechanisms for this remain to be clarified. Not all obese individuals develop insulin resistance or Type 2 diabetes and these perturbations are also seen in non-obese individuals. READ MORE

  4. 2. Cell signalling in cancer. A functional and immunochemical investigation of purinergic,adrenergic, nitrergic, and prostaglandin mediated signalling mechanisms in experimental and human cancer

    Author : Gunnar Nylund; Göteborgs universitet; []
    Keywords : adenosine-5´-triphosphate; colon cancer; extracellular acidification; melanoma; ; microphysiometer; nitric oxide; noradrenaline; prostaglandin E2; sarcoma; tumour cell; metabolism; uridine-5´-triphosphate;

    Abstract : Disturbed cell signalling is a hallmark of the cancer cell, being one important mechanismbehind uncontrolled cell growth. In the current study, we have investigated cancer cellsignalling with the focus on some first messenger and/or their receptors, in the murine celllines, MCG 101, and K1735-M2, and the human colon cancer cell line, HT-29. READ MORE

  5. 3. The Cross-Talk between GABA Signalling and Metabolic Hormones in the Brain and Pancreatic Islets

    Author : Yang Jin; Bryndis Birnir; Vidar Gundersen; Uppsala universitet; []
    Keywords : ;

    Abstract : GABA is a well-known neurotransmitter that can be synthesized in the central nervous system (CNS) and, interestingly, also in pancreatic islets. Once released, GABA activates GABA-A channels tonically or transiently resulting in different physiological functions. READ MORE

  6. 4. Regulation of Platelet-Derived Growth Factor Receptor Signaling and its Targeting in Cancer Therapy

    Author : Haisha Ma; Johan Lennartsson; Håkan Axelson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; PDGFR; Ras; macropinocytosis; Fer; STAT3; HD-PTP; Cbl; ubiquitination; pericyte; vasculature; tumor; ASKA; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Abstract : Overactivity of platelet-derived growth factor receptor (PDGFR) is a frequent event in many types of solid tumors. Therefore, it is of great importance to uncover the mechanisms that regulate PDGF/PDGFR signalling, to develop efficient inhibitors targeting this pathway. READ MORE

  7. 5. Transforming growth factor-ß. Signal regulation in health and disease

    Author : Urban Molander; Göteborgs universitet; []
    Keywords : TGF-b; BMP; Smad; signal transduction; LDL; skin tumour; mesangial;

    Abstract : TGF-b superfamily members have been shown to play a pivotal role in multicellular organisms. Knowledge about signal transduction pathways is important in order to understand and cure diseases like cancer where TGF-b´s growth inhibitory signal often are disenabled via mutated or absent signalling components. READ MORE