Search for dissertations about: "autocrine stimulation"
Showing result 1 - 5 of 35 swedish dissertations containing the words autocrine stimulation.
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1. Autocrine growth stimulation in human bladder cancer
Abstract : Bladder cancer is one of the most common human cancers which, on a worldwide basis, represents 3-4 % of all malignancies. It is primarily occuring in people over 60 and males are about 2-3 times more likely to develop bladder cancer than are women. READ MORE
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2. Roles of p16INk a and PDGF-B in glioma
Abstract : Gliomas are diffuse astrocytic tumors of the central nervous system (CNS) which usually affect adults. This thesis work has focused on molecular mechanisms of altered growth control in glioma, and the significance of two gene products belonging to pathways commonly affected in glioma, p16INK4a and PDGF-B, has been investigated in vitro and in vivo. READ MORE
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3. Functional Studies on the PDGFR α gene promoter and effects of autocrine PDGF-A stimulation in vivo
Abstract : Platelet-derived growth factor receptor α (PDGFRα) plays an important role during embryogenesis. After implantation, the patterns of expression of Pdgfrα and its ligand Pdgf-A undergo an "autocrine-paracrine transition", in that Pdgf-A becomes expressed in the ectoderm and epithelia, while Pdgfrα is expressed in the adjacent mesenchymal tissue. READ MORE
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4. Paracrine and autocrine functions of PDGF in malignant disease
Abstract : Growth factors and their receptors are frequently activated by mutations in human cancer. Platelet-derived growth factor (PDGF)-B and its tyrosine kinase receptor, the PDGF β-receptor, have been implicated in autocrine transformation as well as paracrine stimulation of tumor growth. READ MORE
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5. The role of PDGFB in dermatofibrosarcoma protuberans and giant cell fibroblastoma
Abstract : Dermatofibrosarcoma protuberans (DFSP) and giant cell fibroblastoma (GCF) are rare invasive tumors of the dermis. GCF is considered the juvenile form of DFSP. Both DFSP and GCF are characterized by the presence of chromosomal aberrations involving chromosomes 17 and 22. READ MORE