Search for dissertations about: "autoimmunity"

Showing result 11 - 15 of 413 swedish dissertations containing the word autoimmunity.

  2. 11. Resistin is a modulator of inflammation and autoimmunity

    Author : Elisabeth Almer Boström; Göteborgs universitet; []
    Keywords : Resistin; inflammation; autoimmunity; rheumatoid arthritis; Sjögren s syndrome;

    Abstract : Resistin is a protein with proinflammatory properties in man and a regulator of glucose metabolism in mice. Human resistin activates the nuclear factor kappa-B dependent cytokine cascade; however, its full role in inflammation in terms of regulation, expression, and cellular source is not entirely understood. READ MORE

  4. 12. CD1d restricted NKT cells in regulation of pathogenic autoimmunity

    Author : Anna Teige; Neurokirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Autoimmunity; NKT cells; CD1d antigen presentation; Multiple sclerosis; Rheumatoid arthritis;

    Abstract : Human autoimmune diseases such as reumatoid arthritis (RA) and multiple sclerosis (MS) are believed to develop when self-tolerance mechanisms are failing, with a chronic destructive inflammation as result. To experimentally study autoimmunity, we have used murine models that mimic their human counterparts; experimental autoimmune encephalomyelitis (EAE) – a model for MS, and collagen induced arthritis (CIA) and antigen induced arthritis (AIA) – models for RA. READ MORE

  5. 13. Genetic characterization to dissect the phenotypic complexity of autoimmunity

    Author : Jenny C Karlsson; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; epistasis; EAE; autoimmunity; Immunology; CIA; QTL;

    Abstract : Autoimmune diseases are dependent on multiple genes and unknown environmental factors. Great efforts in the identification of genes conferring susceptibility to autoimmune diseases like Rheumatoid Arthritis (RA) and Multiple Sclerosis (MS) have recently been rewarding. READ MORE

  6. 14. The Role of Reactive Oxygen Species in Animal Models of Autoimmunity

    Author : Malin Hultqvist; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mice; Phytol; ROS; NOX; NADPH; p47phox; Ncf1; EAE; inflammation; Arthritis; RA; MS; Rats; Autoimmunity;

    Abstract : Reactive oxygen species (ROS) produced by the phagocyte NADPH oxidase complex are important in the killing of invading pathogens. Lately, a role of ROS has been suggested in regulation of the immune system. READ MORE

  7. 15. Autoimmunity in Africa: Comparing Systemic Lupus Erythematosus and Anti-phospholipid Antibodies in Sudan and Sweden

    Author : Sahwa Elbagir; Johan Rönnelid; Iva Gunnarsson; Amir I Elshafie; Bo Nilsson; Cem Gabay; Uppsala universitet; []
    Keywords : SLE; anti-phospholipid antibodies; IgA; immune complexes; pregnancy; autoimmunity; Sudan; Africa; Klinisk immunologi; Clinical Immunology;

    Abstract : Systemic Lupus Erythematosus (SLE) is a chronic immune complex (IC)-mediated disease with variable prevalence worldwide, reported to be more common in Africans, Hispanics and Asians than in Caucasian populations. Expression of autoantibodies might vary between different ethnic populations due to environmental and genetic factors. READ MORE