Search for dissertations about: "autoreactive"

Showing result 1 - 5 of 83 swedish dissertations containing the word autoreactive.

  2. 1. Diversity of CD1d-restricted natural killer T cells

    Author : Markus Sköld; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; Immunology; autoreactive; Ly49 receptor; CD1d; NKT cell; transplantation; Immunologi; serologi;

    Abstract : The present study deals with natural killer (NK) T cells restricted to the antigen presenting molecule CD1d. NKT cells have been suggested to play a role in many diverse immunological situations such as clearance of different pathogens, protection against certain tumors, regulation of autoimmune reactions and as a link between innate and adaptive immune responses. READ MORE

  4. 2. Positional cloning of polymorphic loci that control autoreactive T cells

    Author : Mike Aoun; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Autoimmune diseases are expensive diseases, both financially and socially, because they are in most cases life long and require a long-lasting treatment. They can also be life threatening, as they are among top 10 causes of death in women and therefore, they represent a serious clinical problem and require careful medical management. READ MORE

  5. 3. Analysis and manipulation of autoreactive and tumor-specific T cell responses

    Author : Jelena Petrovic; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Autoimmune Diabetes Mellitus; T cell immune response; proteasome inhibitor;

    Abstract : The focus of this work has been on the analysis and manipulation of T cell responses. One emphasis has been on T cells involved in autoimmune diabetes and another on T cells in tumor immunity. Primary activation of T cells as well as the role of the proteasome in T cell responses has been overlapping themes. READ MORE

  6. 4. The T cell phenotype and receptor repertoire in different stages of rheumatoid arthritis : an immunological timeline

    Author : Sara Turcinov; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Rheumatoid arthritis (RA) is a systemic autoimmune disease, characterized by symmetrical inflammation in hands and feet. Antibodies recognizing citrullinated protein (ACPA) and/or rheumatoid factor (RF) are found in most patients and associates with a worse prognosis. Genetic predisposition (i.e. READ MORE

  7. 5. Innate mechanisms regulating peripheral B cell tolerance

    Author : Fredrik Wermeling; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Our immune system protects us from invading pathogens such as bacteria, viruses, fungi and parasites. However, it can also cause disease by being improperly activated against our own tissues (autoimmune diseases) and harmless environmental factors (allergy). READ MORE