Search for dissertations about: "axonal outgrowth"

Showing result 1 - 5 of 31 swedish dissertations containing the words axonal outgrowth.

  2. 1. Phospholipase A2 in nerve injury and axonal outgrowth

    Author : Marie Hornfelt; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Neurology; cell death; apoptosis; leukotrienes; arachidonic acid; M-type receptor; secretory phospholipase A2; cytosolic phospholipase A2; sciatic nerve; dorsal root ganglia; growth cone; axonal outgrowth; nerve injury; peripheral nerve regeneration; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; Animal physiology; Djurfysiologi;

    Abstract : This thesis deals with processes coupled to injury in the peripheral nervous system (PNS), with a general aim to investigate the role of phospholipase A2 (PLA2) enzymes in axonal outgrowth. The axonal outgrowth of dorsal root ganglia (DRG) neurons in vitro was reduced by several different inhibitors of PLA2 activity and enhanced by an activator of this enzyme. READ MORE

  4. 2. Controlled axonal outgrowth and cell reactions to nanostructures

    Author : Fredrik Johansson; Funktionell zoologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Contact guidance; neuron; axon; fibroblast; macrophage; polymethylmethacrylate; porous silicon; nanowire; magnetic; immunoresponse; nanoimprint lithography; haptotaxis;

    Abstract : The interface between living cells and artificial surfaces are highly relevant for biomedical applications such as implants and organized cell growth for tissue reconstruction as well as for basic science purposes. In the present thesis, we have studied axonal guidance on various nano-patterned surfaces such as polymethyl-meth-acrylate, porous silicon and on magnetically aligned Ni nanowires. READ MORE

  5. 3. Tendon autografts for bridging nerve defects

    Author : Jerker Brandt; Malmö Handkirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; traumatology; Surgery; orthopaedics; cell culture; graft; rat; collagen; tendon; Schwann cells; axons; Peripheral nerve regeneration; axonal outgrowth; Kirurgi; ortopedi; traumatologi;

    Abstract : A new method, where a tendon segment – a tendon autograft – was used as graft material for peripheral nerve reconstruction, was developed. Defects, 10-15 mm long, in rat sciatic nerves were bridged by various modifications of tendons. READ MORE

  6. 4. Vascular Endothelial Growth Factor (VEGF) and Peripheral Nerve Regeneration

    Author : Mariann Sondell; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Schwann cell; SCG; rat; peripheral nerve regeneration; neuropilin-1; nerve repair; mouse; growth factor; flk-1; axonal outgrowth; DRG; VEGF; Animal physiology; Djurfysiologi;

    Abstract : This thesis concerns vascular endothelial growth factor (VEGF) and its possible role as a neurotrophic factor. I have investigated the effect of VEGF on neurons in culture but also in vivo, following a crush lesion of the sciatic nerve, and following nerve repair. READ MORE

  7. 5. Nanowires for Cell Research

    Author : Waldemar Hällström; Fasta tillståndets fysik; []
    Keywords : Nanotoxicology; Nanowires; Nanotubes; Nerve Cells; Cell Probing; Force Measurements; Nanotechnology; Axonal Guidance; Fysicumarkivet A:2010:Hällström;

    Abstract : This study explores the interaction between living biological cells and semiconductor nanowires. Biological cells are highly complex and dynamic entities, every one of them with individual characteristics and a high degree of internal and external communication. READ MORE