Search for dissertations about: "azathioprine"

Showing result 16 - 20 of 23 swedish dissertations containing the word azathioprine.

  2. 16. Post-transplantation Hypercholesterolaemia

    Author : Osama Al Rayyes; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thiazolidinediones; transplantation; low density lipoprotein; insulin; indomethacin; hydrocortisone; fluvastatin; flufenamic acid; Cholesterol; cyclosporine; troglitazone.; Immunology; serology; Immunologi; serologi;

    Abstract : The multidrug regimen, cyclosporine, corticosteroids, and azathioprine, is used in transplantation centres to prevent organ rejection. Several clinical studies have shown that cyclosporine and corticosteroids to cause increases in low density lipoprotein (LDL)-cholesterol, with subsequent development of atherosclerosis. READ MORE

  4. 17. Pharmacogenetic studies of thiopurine methyltransferase genotype-phenotype concordance and effect of methotrexate on thiopurine metabolism

    Author : Anna Zimdahl; Malin Lindqvist Appell; Lars-Göran Mårtensson; Inger Johansson; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The thiopurines (6-mercaptopurine [6-MP], 6-thioguanine and azathioprine) are cytotoxic drugs used in the treatment of acute lymphoblastic leukemia (ALL), inflammatory bowel diseases, certain autoimmune diseases and after transplantation. The metabolism of thiopurines is complex with several enzymes involved in the conversion into active drug metabolites. READ MORE

  5. 18. Long-term outcome of renal transplantation in childhood

    Author : Märta Englund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adolescent; Adult height; Cadaver donor; Child; Glomerular filtration rate; Growth; Immunosuppression; Infant; Kidney Transplantation; Living Donor; Renal function; Renal reserve; Survival Analysis;

    Abstract : The aim of this thesis was to evaluate the long-term results of renal transplantation in children at Huddinge University Hospital, with special reference to outcome. We therefore evaluated the course of events in children (age 0.1-16 years) transplanted between December 1981 and December 1991 during a 10-20-year period until 2001. READ MORE

  6. 19. Bone mineral density in pediatric inflammatory bowel disease

    Author : Susanne Schmidt; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bone mineral density; inflammatory bowel disease; children; Crohn s disease; ulcerative colitis; vitamin D; parathyroid hormone; familial resemblance; body composition; growth;

    Abstract : Low bone mineral density (BMD) has been highlighted as a potential problem in children with inflammatory bowel disease (IBD), which is one of the most common chronic childhood diseases in the westernized world. The mechanisms behind reduced BMD in pediatric IBD are still not completely understood, but several factors that influence bone mineralization have been discussed. READ MORE

  7. 20. Interindividual differences in thiopurine metabolism : studies with focus on inflammatory bowel disease

    Author : Sofie Haglund; Sven Almer; Jan Söderman; Curt Peterson; Åke Nilsson; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The thiopurines, 6-mercaptopurine and its prodrug azathioprine, are used in the treatment of inflammatory bowel disease, ulcerative colitis and Crohn´s disease. The main active metabolites are the phosphorylated thioguanine nucleotides (6-TGNs) and methylated thioinosine monophosphate (meTIMP). READ MORE