Search for dissertations about: "bFGF"

Showing result 16 - 20 of 39 swedish dissertations containing the word bFGF.

  2. 16. Predictive Factors in Esophageal Carcinoma

    Author : Martin Dreilich; Michael Bergqvist; Anders Larsson; Daniel Brattström; Gunnar Wagenius; Claes Mercke; Uppsala universitet; []
    Keywords : Oncology; Esophageal carcinoma; Survival; Prognosis; Angiogenesis; HER-2; Telomerase; FMCA; HPV; Onkologi;

    Abstract : Esophageal carcinoma is a malignancy with a poor prognosis and is the sixth cause of cancer related death worldwide. In Sweden approximately 400 new cases are diagnosed every year. The aim of this present thesis was to investigate predictive factors for esophageal carcinoma patients. READ MORE

  4. 17. Regulation of CGRP expression in rat spinal motoneurons

    Author : Fredrik Piehl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : immunohistochemistry; in situ hybridization; motoneuron; axotomy; peptides; CGRP; trophic factor; FGF; IGF; BDNF; CNTF; GAP-43; cell culture; plasticity; mRNAregulation; regeneration;

    Abstract : The normal distribution and lesion-induced changes in the expression of neuropeptides and growth-related proteins, with special reference to calcitonin gene-related peptide (CGRP),were studied in the motor system of the rat. In addition, factors that influence the expression of CGRP in motoneurons were identified. READ MORE

  5. 18. Vascular receptor changes in ischemic stroke

    Author : Emelie Stenman; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vascular receptor changes; Ischemic stroke; Endothelin; Angiotensin; Cardiovascular system; Kardiovaskulära systemet; Pharmacological sciences; pharmacognosy; pharmacy; farmakognosi; farmaci; toxikologi; toxicology; Farmakologi;

    Abstract : The present thesis aimed to examine how ischemic stroke affects the vascular endothelin and angiotensin systems in cerebral arteries. To study vascular receptor changes in ischemic stroke transient focal ischemia was induced in rats. READ MORE

  6. 19. Implantable bioartificial hybrids for targeted therapy in the central nervous system

    Author : Lars U Wahlberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The rapid increase in the understanding of the CNS at the molecular level has brought us new knowledge and tools to attempt to locally manipulate the CNS microenvironment and thereby introduce reparative and ablative molecular therapeutic approaches in focal areas of the CNS. This targeted therapy will require neurosurgical intervention for the injection and implantation of cells, viral vectors, or drug release systems. READ MORE

  7. 20. The expression and function of protein kinase C isoforms in differentiating neuroblastoma cells

    Author : Sofia Fagerström; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; neurophysiology; neuropsychology; Neurology; p130cas; PKC; fte-1; neuroblastoma; SH-SY5Y cells; growth cones; neuronal differentiation; neuropsykologi; neurofysiologi;

    Abstract : The human neuroblastoma cell line SH-SY5Y can be induced to differentiate into a neuronal sympathetic phenotype after treatment with 16 nM 12-O-tetradecanoyl phorbol 13-acetate (TPA) in serum, or by a combination of the growth factors basic fibroblast growth factor and insulin-like growth factor-I (bFGF/IGF-I). SH-SY5Y cells stably transfected with TrkA, the nerve growth factor (NGF) receptor, differentiate in response to NGF. READ MORE