Search for dissertations about: "base damage"

Showing result 1 - 5 of 89 swedish dissertations containing the words base damage.

  2. 1. Oxidative damage and the DNA glycosylase MutYH

    Author : Kristina Jansson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Oxidative damage; 8-oxo-7; 8-dihydro-2′-deoxyguanosine; Base excision repair; DNA glycosylase; Mismatch repair; DNA damage checkpoint; 9-1-1 complex; Glutathione-S-transferases; Colon cancer.;

    Abstract : The DNA glycosylase MutYH is highly conserved throughout evolution, and homologs are found in most eukaryotes and prokaryotes examined. MutYH functions as a base excision repair DNA glycosylase that excises adenines misincorporated opposite 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), one of the most stable products of oxidative DNA damage. READ MORE

  4. 2. Skull base meningioma : Surgical and adjuvant treatment with clinical and PET evaluation

    Author : Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Meningioma; cerebellopontine angle; translabyrinthine and transcochlear approaches; facial nerve; steretactic irradiation; proton beam therapy; interferon- alpha; PET; 11C-L-methionine; 76BR-BrdU; Neurovetenskap; Neurology; Neurologi; Medicine; medicin;

    Abstract : The treatment strategy for skull base meningiomas remains a controversial issue. Because of the proximity of these tumours to critical neurovascular structures, the risk for vascular damage and new cranial neuropathies postoperatively is significant. READ MORE

  5. 3. Modeling DNA Damage

    Author : Patric Schyman; Aatto Laaksonen; Sason Shaik; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA; Ionizing radiation; DNA radicals; Strand break; Hydrogen abstraction; Density Functional Theory; Car-Parrinello Molecular Dynamics; QM MM; Physical chemistry; Fysikalisk kemi; Physical Chemistry; fysikalisk kemi;

    Abstract : In this thesis methods of computational chemistry have been used to examine DNA damaging processes initiated by ionizing radiation, free radicals, or Low-Energy Electrons (LEE). The computational chemistry method based on quantum mechanics that has been mainly used here is the Density Functional Theory (DFT). READ MORE

  6. 4. Blue light induced retinal damage

    Author : Jiangmei Wu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Visual perception results from a response to radiation between 400 and 760 mu reaching the retina. Photoreceptor cells are differentiated post-mitotic retinal neurons uniquely adapted for the efficient capture of photons and for the initiation of visual transduction. READ MORE

  7. 5. Parameters affecting the functionality of additives in lubricated contacts : effect of base oil polarity

    Author : Aldara Naveira Suarez; Luleå tekniska universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Maskinelement; Machine Elements;

    Abstract : Traditionally rolling contact fatigue observed in bearing field applications was subsurface initiated. However, despite the improvement of steel properties, some factors such as downsizing in bearing design, extreme loading of the bearings as well as demanding application conditions (start up-stop cycles) have led to an increase on the cases of surface damage related to surface initiated fatigue, that comes basically from surface distress. READ MORE