Search for dissertations about: "basic level"

Showing result 11 - 15 of 1040 swedish dissertations containing the words basic level.

  2. 11. Molecular Characterisation and Prognostic Biomarker Discovery in Human Non-Small Cell Lung Cancer

    Author : Karolina Edlund; Patrick Micke; Martin Schuler; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; non-small cell lung cancer; biomarker; prognosis; microarray; copy number aberration; Medical Science; Medicinsk vetenskap;

    Abstract : Non-small cell lung cancer (NSCLC) constitutes a clinically, histologically, and genetically heterogeneous disease entity that represents a major cause of cancer-related death. Early-stage patients, who undergo surgery with curative intent, experience high recurrence rates and the effect of adjuvant treatment is modest. READ MORE

  4. 12. Selection of transthyretin amyloid inhibitors

    Author : Irina Iakovleva; Anders Olofsson; Göran Larsson; Bente Westergaard; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transthyretin; TTR; ATTR; TTR-stabilizing drugs; selectivity; medicinsk biokemi; Medical Biochemistry;

    Abstract : Amyloidosis is a group of clinical disorders caused by the aggregation of specific proteins into abnormal extracellular deposits. Today, 31 different proteins have been linked to amyloid diseases including transthyretin-related amyloidosis (ATTR). READ MORE

  5. 13. TNF-α and neurotrophins in Achilles tendinosis

    Author : Johan Bagge; Sture Forsgren; Tomas Movin; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Achilles tendon; tendinosis; tendinopathy; neurotrophins; TNF-alpha; physical acitivity; apoptosis; proliferation; pain; remodelling; anatomi; Human Anatomy;

    Abstract : Tenocytes are the principal cells of the human Achilles tendon. In tendinosis, changes in the metabolism and morphology of these cells occur. Neurotrophins are growth factors essential for the development of the nervous system. READ MORE

  6. 14. HIV disease progression - Impact of HIV-1 intersubtype recombination and association with HIV-2 evolution

    Author : Angelica Palm; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) are both causative agents of AIDS, with similar pathogenic characteristics. However, the rate of disease progression is highly variable both within and between HIV-1 and HIV 2, but the mechanisms involved in modulating the rate of disease progression remain poorly understood. READ MORE

  7. 15. Perilipin expression in the islets of Langerhans and Surface expression in the baculovirus/insect cell system

    Author : Jörgen Borg; Molekylär endokrinologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biology; Biologi; lipotoxicity; beta-cell; perilipin; amino-terminal anchor; Baculovirus; surface display;

    Abstract : Surface display in insect cells: Systems available for surface display that utilize bacterial phages are insufficient for displaying a number of eukaryotic proteins. By instead presenting proteins on the surface of eukaryotic cells or virus, some of these problems might be overcome. READ MORE