Search for dissertations about: "basic level"
Showing result 16 - 20 of 1040 swedish dissertations containing the words basic level.
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16. The role of phosphodiesterase 3B in energy metabolism
Abstract : Energy metabolism at the level of any particular tissue is tightly regulated by hormones, neurotransmitters and cytokines in order to maintain overall energy homeostasis. Any dysfunctions in energy metabolism may lead to more or less severe consequences, with obesity and type 2 diabetes being the most prevalent ones. READ MORE
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17. Specific genetic modifications in the CNS - Cell specific expression and gene specific regulation
Abstract : Gene therapy is a promising therapeutic tool for many diseases of the CNS. Lentiviral vectors are particularly attractive since this vector type can transduce both dividing and non-dividing cells, have a relatively large cloning capacity, can sustain long-term transgene expression and have low immunogenicity. READ MORE
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18. Molecular biosignatures and gut-barrier alterations in inflammatory bowel diseases
Abstract : Inflammatory bowel diseases (IBD) are chronic immune-mediated disorders affecting the gastrointestinal tract. The multifactorial pathophysiology of IBD is commonly explained as an abnormal interplay between genetic, immune, environmental and microbial factors. READ MORE
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19. TNFalpha expression in monocytes/macrophages
Abstract : The recognition of microbes or microbial products by leukocytes is a key event in innate immunity. Binding of microbial products to cell surface receptors on phagocytes induce a response that includes the production of inflammatory mediators. One such mediator is the cytokine tumour necrosis factor alpha (TNF). READ MORE
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20. An Associative Memory Trace in the Cerebellar Cortex
Abstract : Classical conditioning of motor responses, e.g., the eyeblink response, depends on the cerebellum. In the theoretical works of David Marr (1969) and James Albus (1971), it was proposed that Purkinje cells in the cerebellar cortex learn to associate the neutral conditioned stimulus with the response. READ MORE