Search for dissertations about: "benzodiazepine"

Showing result 1 - 5 of 38 swedish dissertations containing the word benzodiazepine.

  1. 1. Pharmacophore Refinement and Lead Optimization - A study of the benzodiazepine site of the GABAA receptors

    Author : Erik Lager; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; Naturvetenskap; Natural science; Quinolone; Flavone; Pharmacophore; GABA; Benzodiazepine;

    Abstract : Structure activity relationship studies of synthetic flavone derivatives have been utilized to refine and evaluate a pharmacophore model of the benzodiazepine binding site of the GABAA receptors, originally developed by Zhang et al. (Drug Des. Discovery 1995, 12, 193-248). READ MORE

  2. 2. Benzodiazepine and opioid dependence. Clinical and meta-analytical studies

    Author : Björn Axel Johansson; Kliniskt Centrum för Hälsofrämjande Vård; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; clinical psychology; psychosomatics; Psychiatry; meta-analysis; opioid dependence; RCT; naltrexone; prescribed drugs; maintenance treatment; methadone; withdrawal symptoms; benzodiazepine dependence; DSM-IV; Psykiatri; klinisk psykologi; psykosomatik;

    Abstract : The thesis contains 4 papers, two clinical studies and two meta-analyses. In the BZD taper study (Paper I) 21 BZD dependent (DSM-IV) patients were included for a 10-day inpatient detoxification. The average defined daily dose (DDD) was 4.7 doses. READ MORE

  3. 3. Taste Hedonics and the Intake of Alcohol and Food

    Author : Anna Söderpalm; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : Alcohol drinking; Adrenalectomy; Corticosterone; Cyanoketone; Food intake; Food restriction; GABA; Metyrapone; Taste reactivity; Benzodiazepine; Chlordiazepoxide; Cis Z -flupentixol; Diazepam; Flumazenil; Microinjections; Midazolam; Nucleus of the Solitary tract; Palatability; Parabrachial nucleus; Peduculopontine Tegmental Nucleus; Reward; 4th ventricle.;

    Abstract : This thesis includes four papers based on animal experimental work. They analyze the way in which activation of a specific motivational state - hunger- modulates the rewarding actions of alcohol and taste palatability. READ MORE

  4. 4. Alcohol problems in women; Gender characteristics relevant for identification in clinical and health screening settings

    Author : Agneta Österling; Kliniskt Centrum för Hälsofrämjande Vård; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; toxicology; pharmacy; pharmacognosy; Pharmacological sciences; questionnaire; immigrant; elderly; benzodiazepine; prevalence; Problem drinking; gender; Farmakologi; farmakognosi; farmaci; toxikologi; Public health; epidemiology; Folkhälsa; epidemiologi;

    Abstract : This thesis presents data relating to gender differences of problem drinking. The aim was to increase the knowledge of characteristics of female problem drinking to enhance identification efficiency. READ MORE

  5. 5. Design and Synthesis of AT2 Receptor Selective Angiotensin II Analogues Encompassing β- and γ-Turn Mimetics

    Author : Ulrika Rosenström; Anders Hallberg; Stephen Hanessian; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Angiotensin II; AT2; AT1; Benzodiazepine; Peptidomimetics; γ-turn; β-turn; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Abstract : Important information on the bioactive conformation of biologically active peptides may be obtained by studies of rigid peptides or well-defined secondary structure mimetics incorporated into pseudopeptides. The structural requirements for the interaction of angiotensin II (Ang II, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) with its AT1 and AT2 receptors were the subject of this study. READ MORE