Search for dissertations about: "beta cell function"

Showing result 1 - 5 of 246 swedish dissertations containing the words beta cell function.

  1. 1. Maf transcription factors in beta cell function

    University dissertation from Stem Cell Center, Lund University

    Author : Elvira Ganic; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Beta cell; MafA; type 2 diabetes; insulin secretion; transcription; monoamine oxidase; MaoA; MaoB; nicotinic receptor subunits; nAChRs;

    Abstract : Popular Abstract in English According to the International Diabetes Federation (IDF), 415 million people suffer from diabetes worldwide. Diabetes occurs when the pancreatic beta cells are no longer able to produce or properly use insulin. Insulin regulates blood glucose levels by enabling glucose uptake into cells, providing the body with energy. READ MORE

  2. 2. Studies of neuropeptides in pancreatic beta cell function with special emphasis on islet amyloid polypeptide (IAPP)

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ella Karlsson; Uppsala universitet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; alpha cell; amylin; beta cell; chromogranin; growth; IAPP; insulin; islet amyloid polypeptide; leptin; NOD mice; pancreastatin; pancreatic islet; proliferation; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : The presence of protein amyloid in pancreas and its association to diabetes was first described 100 years ago in 1901, but was not identified as Islet Amyloid Polypeptide (IAPP) until 1986. The aim of the present work was to determine the role of the beta cell hormone, IAPP, in normal pancreatic islet physiology and during early disturbances of islet function. READ MORE

  3. 3. Protein tyrosine kinases in insulin producing cells : Expression and putative importance for beta-cell function

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Charlotte Öberg-Welsh; Uppsala universitet.; [1997]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Protein tyrosine kinase; insulin producing cells; fetal development; VEGF; Src-family; Bsk; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Protein tyrosine kinases are of importance for cell replication and differentiation in manysystems. The mechanisms controlling the replication and differentiation of insulin producingcells are unknown. READ MORE

  4. 4. TGF-beta signaling in cancer

    University dissertation from Göteborg : Intellecta Infolog AB

    Author : Erik Johansson; Göteborgs universitet.; Gothenburg University.; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-β; proliferation; cancer; tumor suppressor; diffuse-type gastric carcinoma; neuroblastoma; nuclear receptor TLX; cancer stem cell; angiogenesis; ABCG2; VHL; HIF2α; hypoxia; Smad3;

    Abstract : Transforming Growth Factor Beta (TGF-β) is a cytokine regulating a wide range of cellular processes such as proliferation, differentiation, and migration. At the early stages of cancer development TGF-β functions as a tumor suppressor, mainly due to its inhibitory effect on cellular growth, but during cancer progression, mutations in TGF-β signal components switches TGF-β into a promoter of cancer cell proliferation, survival and metastasis. READ MORE

  5. 5. Maf and Mitf transcription factors regulate pancreatic endocrine cell differentiation and function

    University dissertation from Stem Cell Center, Lund University

    Author : Magdalena Mazur; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreas development; beta cells; insulin; MafA; MafB; Mitf; diabetes;

    Abstract : Popular Abstract in Swedish Patienter med diabetes kan inte kontrollera blodsockernivåerna på grund av att de saknar insulinproducerande celler eller har icke fungerande insulinproducerande celler. Det finns olika typer av diabetes där typ 1 diabetes och typ 2 diabetes är de vanligaste formerna. READ MORE