Search for dissertations about: "beta cells"

Showing result 16 - 20 of 631 swedish dissertations containing the words beta cells.

2. 16. Pharmaceutical Protection of Beta-Cells in Diabetes : Using Tyrosine Kinase Inhibition and NOX4 Inhibitors

   Author : Andris Elksnis; Per-Ola Carlsson; Nils Welsh; Sergiu-Bogdan Catrina; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes mellitus; Tyrosine kinase inhibitors; Imatinib; AMPK; Oxidative stress; NADPH-oxidase; NOX; NOX4; Medical Cell Biology; Medicinsk cellbiologi;

   Abstract : Diabetes mellitus is a complex and heterogenous disease, with loss of beta-cell function and mass being a characteristic of not only type 1 diabetes (T1D), but also type 2 diabetes (T2D). In T1D, inappropriate inflammatory signaling is thought to participate in the autoimmune suppression and destruction of beta-cells. READ MORE

4. 17. T cells in atherogenesis

   Author : Anna-Karin L Robertson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : atherosclerosis; T cells; transforming growth factor-beta; CD4; low-density lipoproteins; Th1 Th2; hypercholesterolemia;

   Abstract : The work of this thesis aims to answer the following questions: (1) Which role do CD4+ cells play in atherosclerosis? (2) Is the expression of CD4 essential for the athero-protective effect mediated by immunization with oxidized LDL by adjuvant? (3) How does the antigenspecific T cell response to oxidized LDL influence lesion development? (4) Is there a general shift to Th2 responses in severe hypercholesterolemia? and finally (5) Which role does transforming growth factor-B (TGF-B)-signaling in T cells play in atherogenesis? ApoE-/-CD4-/- mice were used to study the effect of CD4 deficiency in atherosclerosis. The development of atherosclerosis was decreased with attenuated inflammation in apoE-/- mice lacking CD4+ cells compared to immunocompetent apoE-/-. READ MORE

5. 18. Studies of the human pancreas to understand the pathologic events leading to type 1 diabetes

   Author : Louise Granlund; Skog Oskar; Olle Korsgren; Marcus Lundberg; Per Andrén; Teresa Rodriguez-Calvo; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreas; Type 1 Diabetes; Islets of Langerhans; Exocrine tissue; Acinar cells; Islet Microvasculature; Endocrine cells; Extra-islet cells; Insulin; Glucagon; Medicinsk vetenskap; Medical Science;

   Abstract : Type 1 diabetes (T1D) is classically described as a disease emanating from beta-cell loss, and as such, the beta cells have been the main target of investigation. However, recent years have witnessed a shift in perspective, with T1D being increasingly recognized as a condition that affects the entire pancreas. READ MORE

6. 19. Studies of sulfatide expression in relation to beta cell function

   Author : Maria K. Blomqvist; Göteborgs universitet; []
   Keywords : sulfatide; glycosphingolipid; insulin; beta cell; diabetes mellitus; animal models; ; beta cell line;

   Abstract : Previous studies have shown that the glycosphingolipid sulfatide (3´-sulfogalactosyl-ceramide) is present and functionally involved in pancreatic beta cells. In these cells, sulfatide is synthesised as two major isoforms, C16:0 and C24:0 sulfatide, with different length of the fatty acid chain of the ceramide moiety. READ MORE

7. 20. Role of MAP Kinases in the Life and Death of Beta-cells

   Author : Natalia Makeeva; Nils Welsh; Godfried Roomans; Thomas Mandrup-Poulsen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; diabetes; beta-cell; p38 MAPK; nitric oxide; apoptosis; Cellbiologi; Cell biology; Cellbiologi;

   Abstract : The development of diabetes mellitus depends on the balance between beta-cell proliferation and death. As mitogen-activated protein kinases (MAPK) may control this balance, the aim of this study was to investigate the events leading to MAPK activation in beta-cells and the consequences of these events. READ MORE