Search for dissertations about: "beta-secretase"

Showing result 1 - 5 of 7 swedish dissertations containing the word beta-secretase.

  2. 1. Implications of cholesterol and cholesterol-lowering therapy in Alzheimer's disease

    Author : Daniel Famer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alzheimer s disease; dietary cholesterol; rosuvastatin; apolipoprotein E; alpha-secretase; beta-secretase; alpha- beta-secretase ratio; soluble APPalpha; gliosis; microglial load; interleukin-6; caspase-3; body weight gain; lifestyle-preventive strategy; 24 S -hydroxycholesterol; 27-hydroxycholesterol;

    Abstract : BACKGROUND: Alzheimer's disease (AD) is a severe neurodegenerative disease that mainly afflicts elderly persons, with a characteristic progressive decline of cognitive functions and dementia. It is believed that the majority of all AD patients are affected by the sporadic form, thus caused by the combined effects of several risk factors, such as elevated cholesterol levels in midlife and deficiencies in the lipoprotein transporters apolipoprotein E (ApoE). READ MORE

  4. 2. A study of b-secretase cleaved Alzheimer amyloid precursor protein

    Author : Kristina Sennvik; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer's disease (AD) is characterized by the degeneration and loss of neurons, intracellular neurofibrillary tangles and the accumulation of extracellular senile plaques consisting mainly of beta-amyloid (A-beta). A-beta is generated from the amyloid precursor protein (APP) through sequential cleavage by proteases P- and gamma-secretase. READ MORE

  5. 3. Distribution and pathophysiological role of amyloid precursor protein and presenilin 1 : characterization in rats and in vitro studies on the pathogenic arctic mutation

    Author : Camilla Nilsberth; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer's disease is the most common form of dementia that presents a growing dilemma worldwide. Alzheimer's disease is neuropathologically characterized by cerebral atrophy accompanied by deposition of senile plaques and neurofibrillary tangles. READ MORE

  6. 4. Characterization of Diagnostic Tools and Potential Treatments for Alzheimer’s Disease : PET ligands and BACE1 inhibitors

    Author : Fredrik Jeppsson; Anna-Lena Ström; Kerstin Iverfeldt; Samuel Svensson; Martin Hallbeck; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Alzheimer’s disease; Diagnostics; Treatment; PET ligand; BACE1; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Alzheimer’s disease (AD) is a very complex disorder and the most common form of dementia. The two pathological hallmarks of AD are extracellular amyloid-β (Aβ) plaques in cerebral cortex, and intraneuronal neurofibrillary tangles. READ MORE

  7. 5. The role of estrogen regulation in brain development and neurodegeneration

    Author : Linda Nord; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Estrogen is a steroid hormone which regulates neuronal control of reproduction. It has other important roles in the central nervous system (CNS), including trophic effects on dendritic spine morphology that provide structural plasticity. READ MORE