Search for dissertations about: "bicyclo[2.2.2]octane"

Showing result 1 - 5 of 11 swedish dissertations containing the word bicyclo[2.2.2]octane.

  2. 1. Design, synthesis and evaluation of spiro-bicyclo[2.2.2]octane derivatives as paclitaxel mimetics

    Author : Sophie Manner; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; asymmetric baker s yeast reduction; paclitaxel; spiro; bicyclo[2.2.2]octane; paclitaxel mimetics;

    Abstract : Nature contains an endless supply of natural products and has for long been a source of inspiration for the pharmaceutical industry. Many of the drugs currently in clinical use originate from natural products. READ MORE

  4. 2. Synthesis of Spiro-bicyclo[2.2.2]Octane Derivatives Towards the Development of Paclitaxel Mimetics

    Author : Viveca Thornqvist; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Kemi; Organic chemistry; Organisk kemi; Chemistry; Natural science; paclitaxel; spiro; indium; Naturvetenskap; bicyclo[2.2.2]octane; allylation; paclitaxel mimetic;

    Abstract : Many of the drugs that are developed in the pharmaceutical industry have their origin in natural products. Paclitaxel, the active substance of the medicine Taxol, was found in the bark of the Pacific yew tree (Taxus brevifolia). READ MORE

  5. 3. Synthesis of amino- and hydroxyl-substituted bridged bicyclic compounds and their application in asymmetric catalysis

    Author : Cecilia Olsson; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; organocatalysis; asymmetric catalysis; bicyclo[2.2.1]heptane; bicyclo[2.2.2]octane; dibenzobicyclo[3.3.1]nonane; bioreduction; enzymatic kinetic resolution;

    Abstract : In this work, hydroxyl- and amino-substituted bridged bicyclic compounds based on bicyclo[2.2.1]heptane, bicyclo[2.2. READ MORE

  6. 4. Bicyclic Ligands and Catalysts in Asymmetric Synthesis

    Author : Annika Friberg; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; dibenzobicyclo[3.3.1]nonane catecholborane; bicyclo[2.2.2]octane; Asymmetric catalysis; organocatalysis;

    Abstract : Synthesis of compounds based on the structurally rigid bicyclo[2.2.2]octane and the dibenzobicyclo[3.3. READ MORE

  7. 5. Synthesis and evaluation of bicyclic 1,3-diols (BODOLs) as ligands for asymmetric catalysis

    Author : Ian Sarvary; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; yeast reductions; supramolecular chemistry; diethylzinc; computation; structure of Ti-diolates; diol ligands; titanates; asymmetric catalysis; asymmetric synthesis;

    Abstract : Several ligands based upon 2-substituted bicyclic[2.2.2]octane-2,6-diols (BODOLs) were synthesized and evaluated in two catalytic reactions: I) the Ti(IV)-mediated catecholborane asymmetric reduction of prochiral ketones and II) as catalysts in the asymmetric addition of diethylzinc to aromatic aldehydes. READ MORE