Search for dissertations about: "bile acids"

Showing result 11 - 15 of 102 swedish dissertations containing the words bile acids.

  2. 11. Studies on cholesterol homeostasis by modulation of lipoproteins and bile acids

    Author : Lisa-Mari Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cholesterol; lipoproteins; bile acids; cholestyramine; chenodeoxycholic acid; CYP7A1; HNF4alpha; PCSK9; hepatocytes; ethanol; atherosclerosis; ApoE; thyroid hormone receptor;

    Abstract : Excess plasma cholesterol, in particular high levels of LDL cholesterol, is a major risk factor for the development of atherosclerosis. The liver has a central role in the regulation of cholesterol metabolism: i) a major part of the cholesterol present in the body is synthesized in the liver; ii) the level of plasma lipoproteins is regulated by liver uptake and secretion of these particles and iii) the liver is essential for elimination of cholesterol from the body as such or by its conversion into bile acids. READ MORE

  4. 12. On the role of cytochrome P450 3A4 in the metabolism of cholesterol and bile acids

    Author : Karl Bodin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Oxysterols; 4beta-hydroxycholesterol; 1beta-hydroxylated bile acids; 22hydroxylated bile acids; 3-oxo bile acids; gas chromatography-mass spectrometry;

    Abstract : The origin of 4beta-hydroxycholesterol, a major oxysterol in human circulation, has previously been unknown. In this thesis, the formation and elimination of this compound are investigated by various techniques. The biological effects of 4beta-hydroxycholesterol are also discussed. READ MORE

  5. 13. Mechanism-based modeling of biological processes involved in oral absorption

    Author : Benjamin Guiastrennec; Mats O. Karlsson; Martin Bergstrand; Jörg Lippert; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; absorption; bile acids; enterohepatic circulation; food effect; gallbladder; in vitro in vivo correlation; NONMEM; pediatrics; pharmacometrics; tuberculosis; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : For orally administered drugs, the rate and extent of absorption are governed by the physiology of the gastrointestinal tract, the characteristics of the dosage form and the physico-chemical properties of the drug. This thesis primarily aimed to improve the mechanistic understanding and the predictability of processes involved in the absorption of orally administered drugs using a population modeling approach. READ MORE

  6. 14. Cholesterol-lowering and anti-atherogenic effects of oats in mice

    Author : Kristina E Andersson; Cellulär biomekanik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cholesterol; Inflammation; Bile acids; Atherosclerosis; Oats; Beta-glucans;

    Abstract : The cholesterol-lowering effect of oats is well established, but the crucial properties eliciting this effect need to be further investigated to optimize the use of oats as functional foods. Furthermore, there are almost no reports investigating the effect of oats on atherosclerosis development. READ MORE

  7. 15. An insight towards food-related microbial sets through metabolic modelling and functional analysis

    Author : Simonas Marcisauskas; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; RAVEN; gut; systems biology; comparative genomics; Kluyveromyces marxianus; bile acids; genome-scale metabolic model; next-generation sequencing; transcriptomics; thermotolerance;

    Abstract : The dietary food digestion depends on the human gastrointestinal tract, where host cells and gut microbes mutually interact. This interplay may also mediate host metabolism, as shown by microbial-derived secondary bile acids, needed for receptor signalling. Microbes are also crucial in the production of fermented foods, such as wine and dairy. READ MORE