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Found 4 swedish dissertations matching the above criteria.
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1. Assessment of Computational Methods for Ligand Binding
Abstract : Most drugs act on biomacromolecules. The Cost of developing new drugs is very high. A method to accurately predict binding affinities would be very useful. READ MORE
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2. On the estimation of ligand binding affinities
Abstract : A method to accurately estimate the binding affinity of a small molecule to a receptor would be indispensable in numerous fields. For instance, most drugs exert their action by binding to a macromolecule target. Thus, a lot of time and resources could be saved in drug design by predicting affinities by computer programs. READ MORE
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3. Computational prediction of receptor-ligand binding affinity in drug discovery
Abstract : The evaluation of inhibition constants or, more generally, receptor-ligand binding affinities is a crucial part of the drug discovery process. Chemical synthesis and affinity screening is only affordable for a limited number of compounds. This makes computational methods to predict binding affinities of candidate ligands highly desirable. READ MORE
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4. Exploring Ligand Binding in HIV-1 Protease and K+ Channels Using Computational Methods
Abstract : Understanding protein-ligand interactions is highly important in drug development. In the present work the objective is to comprehend the link between structure and function using molecular modelling. READ MORE