Search for dissertations about: "binding affinities"

Showing result 21 - 25 of 117 swedish dissertations containing the words binding affinities.

  2. 21. Ligand binding and enzyme catalysis studied by molecular dynamics simulations

    Author : Tomas Hansson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; molecular dynamics simulation; free energy; linear response; drug design; empirical valence bond; HIV protease; protein tyrosine phosphatase; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Molecular dynamics simulations and free energy calculations can be applied to biomolecular systems to predict ligand binding affinities. Combined with hybrid quantum-classical potential energy surfaces, such computations can also be used to probe enzymatic catalysis mechanisms. READ MORE

  4. 22. Unraveling the molecular mechanisms of herpes simplex virus attachment and release using cell membrane mimics

    Author : Nadia Peerboom; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; total internal reflection fluorescence microscopy; glycosaminoglycans; atomic force microscopy; binding kinetics; single particle tracking; herpes simplex virus;

    Abstract : The herpes simplex virus is a widespread human pathogen, most commonly known for causing cold sores. Its infection cycle is initiated with the formation of multiple bonds between viral glycoproteins and cellular glycosaminoglycans, which are long polysaccharide chains found close to the cell surface. READ MORE

  5. 23. The effect of sequence truncation and amino-acid substitutions on the biophysical properties of protein S and calbindin D9k

    Author : Karin Julenius; Biofysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; surface plasmon resonance; fluorescence spectroscopy; circular dichroism spectroscopy; NMR spectroscopy; hydrophobic effect; protein stability; dimerization; cooperativity; calcium binding; EGF-module; EF-hand; calbindin D9k; protein S; synthet; Physical chemistry; Fysikalisk kemi;

    Abstract : Protein S is a modular protein and a cofactor in the protein C anticoagulant system. It consists of a Gla-module, a thrombin-sensitive loop, four EGF-modules and a SHBG-like module. READ MORE

  6. 24. Studies of the Neuropeptide Y Receptor Y2 in Human and Zebrafish

    Author : Helena Fällmar; Dan Larhammar; Ingrid Lundell; Nina Mohell; Raquel E. Rodríguez Rodríguez; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Y2-receptor; NPY; PYY; G-protein-coupled receptor; mutagenesis; receptor binding; zebrafish; evolution; Pharmacology; Farmakologi; Farmakologi; Pharmacology;

    Abstract : The G-protein coupled receptors (GPCRs) comprise the largest family of receptors in humans and other vertebrates. They are embedded in the cell membrane and are activated by many different signaling molecules. Activation modulates cellular signal transduction pathways and influences many physiological processes. READ MORE

  7. 25. Biochemical and Physiological Characterization of Nonsymbiotic Plant Hemoglobins

    Author : Nélida Leiva; Tillämpad biokemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hemoglobin; Non-symbiotic hemoglobin; Sugar beet; Ligand binding; Nitric oxide; Gene expression; Gene overexpression; Poplar; Arabidopsis; Lepidium campestre.;

    Abstract : Hemoglobins (Hb) are usually associated with blood in humans. However, these proteins are widely distributed among living organisms. In plants the most known group are the leghemoglobins. Still, other Hbs that not participate in symbiosis are also found. READ MORE