Search for dissertations about: "bioactive ligands"

Showing result 1 - 5 of 16 swedish dissertations containing the words bioactive ligands.

  2. 1. Galanin receptor ligands

    Author : Johan Runesson; Ülo Langel; Lena Mäler; Stockholms universitet; []
    Keywords : Galanin; GALP; GPCR; Agonist; GalR; Chimeric peptide; Inositol phosphate production; Receptor specificity; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Abstract : In the nervous system galanin primarily displays a modulatory role. The galaninergic system consists of a number of bioactive peptides with a highly plastic expression pattern and three different receptors. The lack of receptor subtype selective ligands and antibodies have severely hampered the charac-terization of this system. READ MORE

  4. 2. Galanin receptor ligands : Design, synthesis, characterization and biological effects

    Author : Kristin Webling; Ülo Langel; Tore Bengtsson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Galanin is a 29/30 amino acid long bioactive peptide discovered over 30 years ago when C-terminally amidated peptides were isolated from porcine intestines. The name galanin originates from a combination of the first and last amino acids - G from glycine and the rest from alanine. READ MORE

  5. 3. Computational Modeling of the AT2 Receptor and AT2 Receptor Ligands : Investigating Ligand Binding, Structure–Activity Relationships, and Receptor-Bound Models

    Author : Christian Sköld; Anders Karlén; Anders Hallberg; Torbjörn Lundstedt; Tommy Liljefors; Uppsala universitet; []
    Keywords : Pharmaceutical chemistry; Angiotensin II; AT1; AT2; SAR; bioactive conformation; turn mimetic; peptidomimetic; DISCO; homology model; 3D-QSAR; CoMFA; Farmaceutisk kemi;

    Abstract : Rational conversion of biologically active peptides to nonpeptide compounds with retained activity is an appealing approach in drug development. One important objective of the work presented in this thesis was to use computational modeling to aid in such a conversion of the peptide angiotensin II (Ang II, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe). READ MORE

  6. 4. Isolation, structure and processing of bioactive peptides

    Author : Valentina Bonetto; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Amino acid sequences deduced from DNA sequences do not prove in which forms proteins, peptides and their processed products are present in the tissues. The products of a single gene may give rise to variants of peptides because of post-transcriptional or post-translational processing. READ MORE

  7. 5. Purification, structure and function of bioactive peptides

    Author : Elo Eriste; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Peptides are vitally important molecules and many evoke cellular responses. The completion of several genome sequencing projects has revealed a number of new genes. READ MORE